A. Ichihara

Publications194
h-index51
Citations10,499
Highly Influential Citations167
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Interferon-gamma induces different subunit organizations and functional diversity of proteasomes.
To obtain information on the role of proteasomes in the immune system, we examined the effect of a major immunomodulatory cytokine, gamma interferon (IFN-gamma), on the expressions, structures, and… Expand
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Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells.
Latent multicatalytic protease complexes, named proteasomes, were purified to apparent homogeneity from various eukaryotic sources, such as human, rat, and chicken liver, Xenopus laevis ovary, and… Expand
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Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats.
When rat serum was subjected to gel filtration on a Sephadex G-200 column, a factor, "hepatotropin", that promoted hepatocyte growth in primary culture was separated. Its Mr was about 150 KD and it… Expand
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Purification and subunit structure of hepatocyte growth factor from rat platelets
A hepatocyte growth factor (HGF) that stimulates DNA synthesis of adult rat hepatocytes in primary culture was purified as a homogeneous material from platelets of 1000 rats by a four‐step procedure:… Expand
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A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution.
Rat liver cytosol has low hydrolytic activity against [3H]methylcasein at neutrality, but activity increases greatly on addition of various compounds such as poly-L-lysine, N-ethylmaleimide, and… Expand
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Abnormally high expression of proteasomes in human leukemic cells.
Proteasomes are eukaryotic ring-shaped or cylindrical particles with multicatalytic protease activities. To clarify the involvement of proteasomes in tumorigenesis of human blood cells, we compared… Expand
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Possible mechanism of nuclear translocation of proteasomes
Proteasomes (multicatalytic proteinase complexes), which are identical to the ubiquitous eukaryotic 20S particles, are localized in both the cytoplasm and the nucleus, but the mechanism of their… Expand
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ATP‐dependent reversible association of proteasomes with multiple protein components to form 26S complexes that degrade ubiquitinated proteins in human HL‐60 cells
The role of proteasomes in ubiquitin (Ub)‐dependent protein degradation was studied by analyzing lysates of human promyelocytic leukemia HL‐60 cells by glycerol density gradient centrifugation. High… Expand
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Site-directed mutagenesis of the dual translational initiation sites of the clpB gene of Escherichia coli and characterization of its gene products.
The heat shock protein ClpB in Escherichia coli is a protein-activated ATPase and consists of two proteins with sizes of 93 and 79 kDa. By polymerase chain reaction-aided site-directed mutagenesis,… Expand
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Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures.
A growth factor (HGF) stimulating DNA synthesis of adult rat hepatocytes in primary culture was found in rat platelets. HGF was purified from rat platelets to homogeneity by a three-step procedure:… Expand
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