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C/EBPδ is a crucial regulator of pro-apoptotic gene expression during mammary gland involution
The STAT3 transcription factor is an important initiator of mammary gland involution in the mouse. This work shows that the STAT3 target gene CCAAT/enhancer binding protein delta (C/EBPδ) is a… Expand
Xanthine oxidase inhibitory triterpenoid and phloroglucinol from guttiferaceous plants inhibit growth and induced apoptosis in human NTUB1 cells through a ROS-dependent mechanism.
- K. Lin, A. Huang, +6 authors Chun-Nan Lin
- Biology, Medicine
- Journal of agricultural and food chemistry
- 12 January 2011
A known triterpenoid, β-amyrin (1), and a known and a new phloroglucinol, cohulupone (2) and garcinielliptone P (3), were isolated from the pericarp and heartwood and seed of Garcinia subelliptica,… Expand
Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma
- Y. Pu, Chao-yuan Huang, +9 authors T. Hour
- Medicine, Biology
- Journal of Biomedical Science
- 12 September 2009
Metastatic renal cell carcinoma (RCC) is highly resistant to conventional systemic treatments, including chemotherapy, radiotherapy and hormonal therapies. Previous studies have shown over-expression… Expand
Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species.
- H. Tu, A. Huang, +5 authors C. Lin
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 October 2009
Twenty-three ursolic acid (1) derivatives 2-24 including nine new 1 derivatives 5, 7-11, 20-22 were synthesized and evaluated for cytotoxicities against NTUB1 cells (human bladder cancer cell line).… Expand
Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells.
Bladder cancer is the fourth most common type of cancer in men (ninth in women) in the United States. Cisplatin is an effective agent against the most common subtype, urothelial carcinoma. However,… Expand
CCAAT/enhancer binding protein delta (C/EBPδ, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage
- J. Wang, T. R. Sarkar, +6 authors E. Sterneck
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 30 August 2010
Maintenance of genomic integrity is an essential cellular function. We previously reported that the transcription factor and tumor suppressor CCAAT/enhancer binding protein δ (C/EBPδ, CEBPD; also… Expand
EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dependent expression of ABCB1 (MDR1)
Abstract Recent studies have shown that docetaxel-based chemotherapy confers a survival benefit in patients with castration-resistant prostate cancer (PC). Also epidermal growth factor receptor… Expand
UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity.
Gemcitabine (2'-deoxy-2', 2'-difluorocytidine; Gem) is a nucleoside anti-metabolite and is commonly used for treating various human cancers including human bladder carcinoma. Gemcitabine not only… Expand
Cytotoxic and antioxidant constituents from Garcinia subelliptica.
Two new triterpenoids, garcinielliptones Q (1) and S (3), and a new phloroglucinol, garcinielliptone R (2), were isolated from the seed of Garcinia subelliptica. Their structures were established by… Expand
Involvement of p38 mitogen‐activated protein kinase in acquired gemcitabine‐resistant human urothelial carcinoma sublines
- Y. Kao, Wei-Chi Hsu, +7 authors A. Huang
- Biology, Medicine
- The Kaohsiung journal of medical sciences
- 1 July 2014
Resistance to chemotherapeutic drugs is one of the major challenges in the treatment of cancer. A better understanding of how resistance arises and what molecular alterations correlate with… Expand