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PET/MRI Dual-Modality Tumor Imaging Using Arginine-Glycine-Aspartic (RGD)–Conjugated Radiolabeled Iron Oxide Nanoparticles
TLDR
A bifunctional iron oxide (IO) nanoparticle probe for PET and MRI scans of tumor integrin αvβ3 expression is developed to allow for earlier tumor detection with a high degree of accuracy and provide further insight into the molecular mechanisms of cancer. Expand
Recurrent glioblastoma multiforme: a review of natural history and management options.
TLDR
Although recurrent GBM remains a fatal disease, the literature suggests that a subset of patients may benefit from maximal treatment efforts, and further research effort in all aspects of GBM diagnosis and treatment remains essential to improve the overall prognosis of this disease. Expand
Spinal gout in a renal transplant patient: a case report and literature review.
TLDR
A renal transplant patient who developed fever and acute back pain at the L5 through S1 level secondary to sodium urate deposits is presented, and conservative medical management is appropriate for those with back pain only. Expand
Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel.
TLDR
The results of this study suggest that future clinical multimodality imaging and therapy with VEGF(121)/rGel may provide an effective means to prospectively identify patients who will benefit from VEG fusions therapy and then stratify, personalize, and monitor treatment to obtain optimal survival outcomes. Expand
Are quantum dots ready for in vivo imaging in human subjects?
TLDR
New advances in QD technology such as bioluminescence resonance energy transfer, synthesis of smaller size non-Cd based QDs, improved surface coating and conjugation, and multifunctional probes for multimodality imaging, are likely that human applications of QDs will soon be possible in a clinical setting. Expand
Vascular endothelial growth factor and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy.
TLDR
This review will focus on patents which target VEGF-[A-F] and/or VEGFR-[1-3] for use in anti-cancer treatment and the potential for combinatorial therapies. Expand
Integrin αvβ3-Targeted Radioimmunotherapy of Glioblastoma Multiforme
TLDR
Radioimmunotherapy with 90Y-labeled Abegrin may prove promising in the treatment of highly vascular, invasive, and heterogeneous malignant brain tumors. Expand
Integrin alpha v beta 3 antagonists for anti-angiogenic cancer treatment.
TLDR
This review will focus on the key points and distinguishing factors for patents which use antibodies, RGD peptides, non-RGD peptide sequences, peptidomimetics, and amine salts as alpha(v)beta(3) antagonists. Expand
Long-term follow-up of the surgical management of neuropathic arthropathy of the spine.
TLDR
It is recommended that Charcot spine well tolerated without skin, seating problems, or dysreflexia should be cautiously observed with conservative management and three-column stabilization with either combined anterior-posterior or all posterior approaches with anterior support to obtain and secure greater long-term stability. Expand
Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin alpha(v)beta3-rich tumor cells.
TLDR
These c(RGDyK)-MC-Fe3O4 NPs accumulate preferentially in the integrin alphavbeta3-rich tumor area, which is readily tracked by MRI. Expand
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