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- Publications
- Influence
Amphiphilic transdermal permeation enhancers: structure-activity relationships.
- K. Vávrová, J. Zbytovská, A. Hrabálek
- Chemistry, Medicine
- Current medicinal chemistry
- 31 August 2005
Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of… Expand
Dimethylamino Acid Esters as Biodegradable and Reversible Transdermal Permeation Enhancers: Effects of Linking Chain Length, Chirality and Polyfluorination
- J. Novotny, P. Kováříková, M. Novotný, B. Janůšová, A. Hrabálek, K. Vávrová
- Chemistry, Medicine
- Pharmaceutical Research
- 1 April 2009
PurposeSeries of N,N-dimethylamino acid esters was synthesized to study their transdermal permeation-enhancing potency, biodegradability and reversibility of action. Effects of chirality, linking… Expand
Ceramides in the skin lipid membranes: length matters.
- Barbora Školová, B. Janůšová, +8 authors K. Vávrová
- Chemistry, Medicine
- Langmuir : the ACS journal of surfaces and…
- 6 December 2013
Ceramides are essential constituents of the skin barrier that allow humans to live on dry land. Reduced levels of ceramides have been associated with skin diseases, e.g., atopic dermatitis. However,… Expand
Short-Chain Ceramides Decrease Skin Barrier Properties
- J. Novotný, B. Janůšová, M. Novotny, A. Hrabálek, K. Vávrová
- Chemistry, Medicine
- Skin Pharmacology and Physiology
- 2008
Stratum corneum ceramides are major determinants of skin barrier function. Although their physiological and pathological role has been widely investigated, to date no structure-activity relationships… Expand
Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes.
- B. Janůšová, J. Zbytovská, +4 authors K. Vávrová
- Chemistry, Medicine
- Biochimica et biophysica acta
- 1 March 2011
Stratum corneum ceramides play an essential role in the barrier properties of skin. However, their structure-activity relationships are poorly understood. We investigated the effects of acyl chain… Expand
L-Serine and glycine based ceramide analogues as transdermal permeation enhancers: polar head size and hydrogen bonding.
- K. Vávrová, A. Hrabálek, P. Doležal, T. Holas, J. Zbytovská
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 21 July 2003
Novel transdermal permeation enhancers related to stratum corneum ceramides were investigated. The synthesis of a series of simple compounds based on two selected amino acids, L-serine and glycine,… Expand
Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers.
- K. Vávrová, A. Hrabálek, P. Doležal, T. Holas, J. Klimentova
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 5 May 2005
The purpose of this work was to develop a novel approach to transdermal permeation enhancer design, based on utilizing some favorable properties of their metabolites. As an example of this concept, a… Expand
Transdermal and dermal delivery of adefovir: effects of pH and permeation enhancers.
- K. Vávrová, Kateřina Lorencová, J. Klimentova, J. Novotny, Antoni N Holý, A. Hrabálek
- Chemistry, Medicine
- European journal of pharmaceutics and…
- 1 June 2008
The objective of this work was to investigate feasibility of transdermal and dermal delivery of adefovir (9-(2-phosphonomethoxyethyl)adenine), a broad-spectrum antiviral from the class of acyclic… Expand
1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant…
- Galina Karabanovich, Jaroslav Roh, +9 authors A. Hrabálek
- Chemistry, Medicine
- European journal of medicinal chemistry
- 23 July 2014
In this work, a new class of highly potent antituberculosis agents, 1-substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their oxa and selanyl analogs, is described. The minimal inhibitory… Expand
Enhancement effects of (R) and (S) enantiomers and the racemate of a model enhancer on permeation of theophylline through human skin
- K. Vávrová, A. Hrabálek, P. Doležal
- Chemistry, Medicine
- Archives of Dermatological Research
- 25 September 2002
Abstract. The conformation of a permeation enhancer, given their mechanism of action, could influence its enhancing properties, since the stratum corneum components form essentially a chiral… Expand