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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD:1:CB1:), cloned in 1990, and CB2(2.1:CBD:2:CB2:), cloned in 1993. Distinction between these receptors is based onExpand
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9-tetrahydrocannabinol, numerousExpand
Determination and characterization of a cannabinoid receptor in rat brain.
The determination and characterization of a cannabinoid receptor from brain are reported. A biologically active bicyclic cannabinoid analgetic CP-55,940 was tritium-labeled to high specific activity.Expand
Pharmacology of cannabinoid receptors.
  • A. Howlett
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 1995
Two subtypes of cannabinoid receptors, CB1 and CB2, have been described to date, although future investigations may elucidate other receptors. The actions of cannabimimetic agents via CB1 receptorsExpand
Cannabinoid physiology and pharmacology: 30 years of progress
Delta9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528, through G-protein-coupled receptors,Expand
Cannabinoid receptor signaling.
  • A. Howlett
  • Medicine, Biology
  • Handbook of experimental pharmacology
  • 2005
The cannabinoid receptor family currently includes two types: CB1, characterized in neuronal cells and brain, and CB2, characterized in immune cells and tissues. CB1 and CB2 receptors are members ofExpand
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
The cellular mechanism of action of the cannabimimetic drugs is examined using cultured cells. In membranes from N18TG2 neuroblastoma cells and the neuroblastoma X glioma hybrid cells, NG108-15, theExpand
Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase.
Anandamide amidase (EC is responsible for the hydrolysis of arachidonoyl ethanolamide (anandamide). Relatively selective and potent enzyme reversible inhibitors effective in the lowExpand
The cannabinoid receptors.
  • A. Howlett
  • Chemistry, Medicine
  • Prostaglandins & other lipid mediators
  • 1 August 2002
Cannabinoid receptors were named because they have affinity for the agonist delta9-tetrahydrocannabinol (delta9-THC), a ligand found in organic extracts from Cannabis sativa. The two types ofExpand
The ontogeny of cannabinoid receptors in the brain of postnatal and aging rats.
It is recognized that a number of the biological effects of delta 9-tetrahydrocannabinol (THC) can be attributed to a cannabinoid receptor found in abundance in the brain. Due to observations thatExpand