A. Holohean

Publications41
h-index16
Citations644
Highly Influential Citations19
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5-Hydroxytryptamine 5HT2C Receptors Form a Protein Complex with N-Methyl-d-aspartate GluN2A Subunits and Activate Phosphorylation of Src Protein to Modulate Motoneuronal Depolarization*
Background: 5-Hydroxytryptamine (5HT) modulates N-methyl-d-aspartate (NMDA) depolarization. Results: 5HT2C co-immunoprecipitates with GluN2A and enhances NMDA motoneuronal depolarization through… Expand
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GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons.
Previous studies have demonstrated significant pharmacological differences between the GABA(A) receptors expressed by neurons cultured from embryonic and adult human dorsal root ganglia (DRG).… Expand
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Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex
The putative anti-addiction alkaloid ibogaine and its principal metabolite 12-hydroxyibogamine appear to act at the (+)-5 methyl-10,11,dihydro-5H- dibenzo[a,d]cycloheten-5-10-imine maleate (MK-801)… Expand
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Mechanisms involved in the metabotropic glutamate receptor‐enhancement of NMDA‐mediated motoneurone responses in frog spinal cord
The metabotropic glutamate receptor (mGluR) agonist trans‐(±)‐1‐amino‐1,3‐cyclopentanedicarboxylic acid (trans‐ACPD) (10–100 μM) depolarized isolated frog spinal cord motoneurones, a process… Expand
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The Number of Components of Enhancement Contributing to Short-Term Synaptic Plasticity at the Neuromuscular Synapse during Patterned Nerve Stimulation Progressively Decreases As Basal Release…
Presynaptic short-term plasticity (STP) dynamically modulates synaptic strength in a reversible manner on a timescale of milliseconds to minutes. For low basal vesicular release probability (prob0),… Expand
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Analyzing mechanism(s) of hallucinogenic drug action with drug discrimination procedures
Some of the advantages of using drug discrimination (DD) procedure to analyze the mechanisms of action of hallucinogenic and related drugs were illustrated by reviewing research with lysergic acid… Expand
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Serotonin1A facilitation of frog motoneuron responses to afferent stimuli and toN-methyl-d-aspartate
The effects of serotonin and excitatory amino acids on motoneurons were examined by sucrose gap recordings from the ventral root of the isolated, hemisected frog spinal cord superfused with… Expand
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An in vitro study of the effects of serotonin on frog primary afferent terminals
The effects of serotonin on the membrane potential of primary afferent terminals of isolated hemisected frog spinal cords was investigated by sucrose gap recordings from dorsal root. Serotonin… Expand
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Mechanisms intrinsic to 5‐HT2B receptor‐induced potentiation of NMDA receptor responses in frog motoneurones
In the presence of NMDA receptor open‐channel blockers [Mg2+; (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a,d]cyclohepten‐5,10‐imine maleate (MK‐801); 1‐amino‐3,5‐dimethyladamantane (memantine)] and TTX,… Expand
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Voltage-gated calcium currents in whole-cell patch-clamped bullfrog dorsal root ganglion cells: effects of cell size and intracellular solutions
Acutely dissociated bullfrog dorsal root ganglion (DRG) cells could be divided into two classes by measurement of cell capacitance. A bimodal distribution of cell capacitance was found and a value of… Expand
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