A. Holohean

Publications42
h-index16
Citations666
Highly Influential Citations17
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GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons.
TLDR
Changes in receptor subunit composition may underlie the novel pharmacological properties of GABA(A) receptor responses in adult cells, however, post-translational modification of a known subunit or the expression of a novel subunit may also contribute to the unique pharmacology of these neurons.
Mechanisms involved in the metabotropic glutamate receptor‐enhancement of NMDA‐mediated motoneurone responses in frog spinal cord
TLDR
Group I mGluRs selectively facilitate NMDA‐depolarization of frog motoneurones via a G‐protein, a rise in [Ca2+]i from the presumed generation of phosphoinositides, binding of Ca2+ to calmodulin, and lessening of the Mg2+‐produced channel block of the NMDA receptor.
5-Hydroxytryptamine 5HT2C Receptors Form a Protein Complex with N-Methyl-d-aspartate GluN2A Subunits and Activate Phosphorylation of Src Protein to Modulate Motoneuronal Depolarization*
TLDR
It is demonstrated that activated 5HT2C receptors enhance NMDA depolarizations recorded electrophysiologically from motoneurons and that a distinct multiprotein complex links 5-hydroxytryptamine-activated intracellular signaling events with NMDA-mediated functional activity.
The Number of Components of Enhancement Contributing to Short-Term Synaptic Plasticity at the Neuromuscular Synapse during Patterned Nerve Stimulation Progressively Decreases As Basal Release…
TLDR
Observations place prob0-dependent limitations on which components of enhancement contribute to STP and suggest some fundamental mechanistic differences among the components are suggested.
Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex
TLDR
Results are compatible with the idea that the ability of ibogaine and 12-hydroxyibogamine to interrupt drug-seeking behavior may, in part, result from their actions at the MK-801 binding site.
Serotonin1A facilitation of frog motoneuron responses to afferent stimuli and toN-methyl-d-aspartate
TLDR
8-OH-DPAT significantly enhanced motoneuron depolarizations elicited by the selective excitatory amino acid agonist N-methyl-D-aspartate in both normal and tetrodotoxin-containing Ringer solution.
An in vitro study of the effects of serotonin on frog primary afferent terminals
TLDR
The results suggest that 5- HT released from terminals in the frog dorsal horn could exert a modulatory action on the afferent input of the spinal cord, but different effects generated by activation of different 5-HT receptor subtypes are dependent upon the concentration of the amine.
Mechanisms intrinsic to 5‐HT2B receptor‐induced potentiation of NMDA receptor responses in frog motoneurones
In the presence of NMDA receptor open‐channel blockers [Mg2+; (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a,d]cyclohepten‐5,10‐imine maleate (MK‐801); 1‐amino‐3,5‐dimethyladamantane (memantine)] and TTX,…
Monoamines and extracellular potassium concentration in the amphibian spinal cord.
Benzodiazepine receptor mediated discriminative cues: effects of GABA-ergic drugs and inverse agonists.
TLDR
Since inverse BZ receptor agonists (FG 7142, DMCM and beta-CCM) were, at best, only marginally effective in antagonizing DZP, the DZp cue may be mediated by a distinct subclass of BZ receptors.
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