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Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential
There is a wide variety of cancer types yet, all share some common cellular and molecular behaviors. Most of the chemotherapeutic agents used in cancer treatment are designed to target commonExpand
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Characterisation of six additional human metallothionein genes.
Human metallothionein (MT) genes are clustered in a locus on chromosome 16, and this report presents the characterisation of the remaining six univestigated members of the family. NucleotideExpand
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Recruitment of SWI/SNF to the Human Immunodeficiency Virus Type 1 Promoter
ABSTRACT Following human immunodeficiency virus type 1 (HIV-1) integration into the host cell's genome, the 5′ long terminal repeat (LTR) is packaged into a highly specific chromatin structureExpand
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Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor κB Proteins
Granulocyte/macrophage colony-stimulating factor (GM-CSF) is a key cytokine in myelopoiesis and aberrant expression is associated with chronic inflammatory disease and myeloid leukemias. ThisExpand
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Functional Interaction between the HIV Transactivator Tat and the Transcriptional Coactivator PC4 in T Cells*
The human immunodeficiency virus (HIV) transactivator Tat is a potent activator of transcription from the HIV long terminal repeat and is essential for efficient viral gene expression andExpand
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Fucoidan Suppresses the Growth of Human Acute Promyelocytic Leukemia Cells In Vitro and In Vivo
Fucoidan, a natural component of seaweeds, is reported to have immunomodulatory and anti‐tumor effects. The mechanisms underpinning these activities remain poorly understood. In this study, theExpand
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Epigenetic regulation of inducible gene expression in the immune system
T cells are exquisitely poised to respond rapidly to pathogens and have proved an instructive model for exploring the regulation of inducible genes. Individual genes respond to antigenic stimulationExpand
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Regulation of cytokine gene transcription in the immune system.
The controlled expression of cytokine genes is an essential component of an immune response. The specific types of cytokines as well as the time and place of their production is important inExpand
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GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements
Granulocyte-macrophage colony stimulating factor (GM-CSF) plays a key role in myeloid cell function and is rapidly and transiently expressed in T cells in response to immune or inflammatory stimuli.Expand
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Localisation and expression of metallothionein immunoreactivity in the developing sheep brain
Metallothioneins are small cysteine‐rich proteins that bind heavy metals. In higher mammals there are complex families of metallothionein isoforms, which are well characterised at the DNA level butExpand
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