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Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential
The mechanisms by which fucoidan retards tumor development, eradicates tumor cells and synergizes with anti-cancer chemotherapeutic agents are discussed.
Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor κB Proteins
Results suggest that chromatin remodeling across the GM-CSF promoter in T cells is a result of recruitment of SWI/SNF type remodeling complexes by NF-κB proteins binding to the CD28 response region of the promoter.
The potential role of epigenetic modifications in the heritability of multiple sclerosis
The dynamic epigenetic changes in these aspects of MS pathogenesis are reviewed and how environmental risk factors may interact with epigenetic change to manifest in disease is described.
Fucoidan Suppresses the Growth of Human Acute Promyelocytic Leukemia Cells In Vitro and In Vivo
The cytotoxicity and anti‐tumor activities of fucoidan were investigated in acute myeloid leukemia (AML) cells and its protective effect against APL development in mice warrant further investigation offucoidan as a useful agent in treatment of certain types of leukemia.
Recruitment of SWI/SNF to the Human Immunodeficiency Virus Type 1 Promoter
Analysis of the recruitment of BRG-1 in nuclear extracts prepared from Jurkat T cells and reconstitution of an in vitro system with purified components demonstrate that ATF-3 is responsible for targeting human SWI/SNF (hSWI/ SNF) to the HIV-1 promoter.
Functional Interaction between the HIV Transactivator Tat and the Transcriptional Coactivator PC4 in T Cells*
This interaction has a functional outcome in that PC4 overexpression enhanced activation of the HIV long terminal repeat in transient transfection studies in a Tat-dependent manner, and it is proposed thatPC4 may be involved in linking Tat to the basal transcription machinery.
Epigenetic regulation of inducible gene expression in the immune system
The multi‐layered regulation of inducible gene expression in the immune system is discussed, focusing on the interplay between transcription factors, and the T‐cell epigenome, including the role played by chromatin remodellers and epigenetic enzymes.