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Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.
Low bioavailability of peptides following oral administration is attributed to their inactivation in the gastro–intestinal tract through enhanced enzymatic degradation in the gut wall by a variety ofExpand
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Piperine‐pro‐nanolipospheres as a novel oral delivery system of cannabinoids: Pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration
ABSTRACT Nowadays, therapeutic indications for cannabinoids, specifically &Dgr;9‐tetrahydrocannabinol (THC) and Cannabidiol (CBD) are widening. However, the oral consumption of the molecules is veryExpand
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Modeling of drug release from erodible tablets.
A general mathematical model was developed to describe drug release from erodible tablets undergoing surface erosion. The model (which is based on the Hopfenberg equation) takes into account theExpand
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Pharmacodynamic and pharmacokinetic rationales for the development of an oral controlled-release amoxicillin dosage form.
The goal of this investigation was to develop an oral sustained-release formulation for amoxicillin that would maximize the duration of active drug concentration in the extracellular fluid, thusExpand
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Physicochemical Characterization and Acute Toxicity Evaluation of a Positively‐charged Submicron Emulsion Vehicle
Abstract— Fine, homogeneous, positively‐charged emulsions with a mean droplet size of 138 ± 71 nm and a zeta potential value of 41.06 mV were prepared using a combination of emulsifiers comprisingExpand
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Myocarditis following envenoming with Vipera palaestinae in two horses.
Cardiac disease developed several days to weeks after resolution of local inflammation caused by envenoming by Vipera palaestinae in two horses. In one horse (case A), referred to the hospital forExpand
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Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88
MyD88 is a cytoplasmic adaptor protein that plays a central role in signaling downstream of the TLRs and the IL1R superfamily. We previously demonstrated that MyD88 plays a critical role in EAE, theExpand
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Pharmacokinetic Considerations of New Insulin Formulations and Routes of Administration
SummaryThere is a continuing search for improved insulin formulations in order to imitate as closely as possible the physiological pattern of insulin secretion, and thereby to minimise theExpand
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Mode of administration-dependent pharmacokinetics of bisphosphonates and bioavailability determination.
We investigated the influence of mode of administration on the pharmacokinetics of a clinically used bisphosphonate, pamidronate, and of suberoylbisphosphonate (SuBP), a novel bisacylphosphonate ofExpand
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