A. Hirasawa

Publications206
h-index46
Citations9,070
Highly Influential Citations502
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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
TLDR
It is shown that a G-protein-coupled receptor, GPR120, which is abundantly expressed in intestine, functions as a receptor for unsaturated long-chain FFAs and promotes the secretion of GLP-1 in vitro and in vivo, and increases circulating insulin.
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
TLDR
This study demonstrates that the lipid sensor GPR120 has a key role in sensing dietary fat and, therefore, in the control of energy balance in both humans and rodents.
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
TLDR
It is established that SCFAs and ketone bodies directly regulate GPR41-mediated SNS activity and thereby control body energy expenditure in maintaining metabolic homeostasis.
Free fatty acids induce cholecystokinin secretion through GPR120
TLDR
Results indicate that long-chain FFAs induce CCK secretion through GPR120-coupled Ca2+signaling, which was specifically inhibited by transfection of GPR 120-specific, but not GPR40- specific, short hairpin RNA.
Free Fatty Acids Inhibit Serum Deprivation-induced Apoptosis through GPR120 in a Murine Enteroendocrine Cell Line STC-1*
TLDR
It is shown that FFAs inhibit serum deprivation-induced apoptosis of murine enteroendocrine STC-1 cells, which express two types of GPCRs, GPR120 and GPR40, for unsaturated long chain FFA, and promote the activation of ERK and PI3K-Akt pathways mainly via G PR120, leading to the anti-apoptotic effect of STC1 cells.
Novel selective ligands for free fatty acid receptors GPR120 and GPR40
TLDR
These studies identified a selective GPR40 agonist and several GPR120 partial agonists, and similar profiles of glucagon-like peptide-1 secretion were seen for mouse enteroendocrine cell line, STC-1 cells, which express GPR 120 endogenously.
Implantation and placental development in somatic cell clone recipient cows.
TLDR
Findings strongly support a delay in trophoblast development during early stages of placentation in NT cows, and suggest that placental specific proteins, including PLs, PAGs, and HPA, are key indicators for the aberration of gestation and placental function in cows.
Free fatty acid receptors and drug discovery.
TLDR
The identification, structure, and pharmacology of the receptors are summarized, and the respective physiologic roles that FFA receptor family members may play are speculated on.
Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic β cells
TLDR
Results show that rat GPR120 is a G-protein-coupled receptor whose ligand is a free fatty acid, and it may play an important role in the FFA-associated physiological responses.
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