• Publications
  • Influence
Drug permeation enhancement via buccal route: possibilities and limitations.
  • S. Şenel, A. Hincal
  • Medicine, Chemistry
  • Journal of controlled release : official journal…
  • 14 May 2001
Over the last decade, there has been a particular interest in delivering drugs, especially peptides and proteins via the buccal route. It provides direct entry into the systemic circulation thusExpand
  • 226
  • 8
Diclofenac sodium incorporated PLGA (50:50) microspheres: formulation considerations and in vitro/in vivo evaluation.
Recently, considerable interest has been focused on the use of biodegradable polymers for specialized applications such as controlled release of drug formulations; meanwhile, microsphereExpand
  • 149
  • 7
  • Open Access
In vitro and in vivo studies of ibuprofen-loaded biodegradable alginate beads
The irritation effects of ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID), were evaluated on mouse gastric and duodenal mucosa when suspended in 0.5% (w/v)Expand
  • 60
  • 5
  • Open Access
Enhancing effect of chitosan on peptide drug delivery across buccal mucosa.
The buccal mucosa represents a potentially important topical route for delivery of peptide or protein drugs with some unique advantages such as the avoidance of hepatic first-pass metabolism and theExpand
  • 213
  • 3
Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis.
Local delivery systems of antimicrobial agents for treatment of the periodontal diseases received considerable attention during the past decade due to the disadvantages of the systemicExpand
  • 147
  • 3
Optimization of Spray-Dried and -Congealed Lipid Micropellets and Characterization of Their Surface Morphology by Scanning Electron Microscopy
Lipid micropellets prepared from glycerides and phospholipids may be a physiological drug carrier system for improving the intestinal absorption of lipophilic drugs. They can be prepared byExpand
  • 136
  • 3
Amphiphilic cyclodextrin nanoparticles.
Cyclodextrins are cyclic oligosaccharides obtained by enzymatic digestion of starch. The α-, β- and γ- cyclodextrins contain respectively 6, 7 and 8 glucopyranose units, with primary and secondaryExpand
  • 38
  • 3
Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery.
Topical delivery of antimicrobial agents is the most widely accepted approach aimed at prolonging active drug concentrations in the oral cavity. As most antifungals do not posses inherent ability toExpand
  • 265
  • 2
In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium.
The dispersion of non-steroidal antiinflammatory drugs (NSAIDs) into biodegradable polymeric matrices have been accepted as a good approach for obtaining a therapeutic effect in a predeterminedExpand
  • 63
  • 2
  • Open Access
The effects of lyophilization on the stability of liposomes containing 5-FU.
Multilamellar liposomes containing 5-fluorouracil (5-FU) were prepared by modified lipid film hydration method and were lyophilized with or without saccharose as cryoprotectant. The effect ofExpand
  • 111
  • 2
  • Open Access