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Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
Reactive oxygen (RO) has been identified as an important effector in ageing and lifespan determination. The specific cell types, however, in which oxidative damage acts to limit lifespan of the wholeExpand
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Mapping simple repeated DNA sequences in heterochromatin of Drosophila melanogaster.
Heterochromatin in Drosophila has unusual genetic, cytological and molecular properties. Highly repeated DNA sequences (satellites) are the principal component of heterochromatin. Using probes fromExpand
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RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila.
The mitochondrial iron chaperone, frataxin, plays a critical role in cellular iron homeostasis and the synthesis and regeneration of Fe-S centers. Genetic insufficiency for frataxin is associatedExpand
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RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress
Oxidative stress has been widely implicated as an important factor in the aging process. Because mitochondrial respiration is the principal source of reactive oxygen within cells, the mitochondriallyExpand
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Meiotic gene conversion tract length distribution within the rosy locus of Drosophila melanogaster.
Employing extensive co-conversion data for selected and unselected sites of known molecular location in the rosy locus of Drosophila. we determine the parameters of meiotic gene conversion tractExpand
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Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.
The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2 toxicity in Drosophila is examined through theExpand
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Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: deficiency mapping of EMS-induced lethal complementation groups.
Until recently, little was known of the genetic constitution of the heterochromatic segments of the major autosomes of Drosophila melanogaster. Our previous report described the genetic dissection ofExpand
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Heterochromatin protein 1 is required for the normal expression of two heterochromatin genes in Drosophila.
The Su(var)2-5 locus, an essential gene in Drosophila, encodes the heterochromatin-associated protein HP1. Here, we show that the Su(var)2-5 lethal period is late third instar. Maternal HP1 is stillExpand
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Urate-null rosy mutants of Drosophila melanogaster are hypersensitive to oxygen stress.
It has been proposed that uric acid is an important scavenger of deleterious oxygen radicals in biological systems [Ames, B. N., Cathcart, R., Schwiers, E. & Hochstein, P. (1981) Proc. Natl. Acad.Expand
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Compartment-specific Protection of Iron-Sulfur Proteins by Superoxide Dismutase*
Iron and oxygen are essential but potentially toxic constituents of most organisms, and their transport is meticulously regulated both at the cellular and systemic levels. Compartmentalization may beExpand
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