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Drosophila separase is required for sister chromatid separation and binds to PIM and THR.
Drosophila PIM and THR are required for sister chromatid separation in mitosis and associate in vivo. Neither of these two proteins shares significant sequence similarity with known proteins.Expand
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A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes
Despite the fundamental role of canonical histones in nucleosome structure, there is no experimental system for higher eukaryotes in which basic questions about histone function can be directlyExpand
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A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb
Genetic Epigenetics Posttranslational modifications of histone proteins have been implicated in the regulation of gene transcription in organisms ranging from yeast to humans. However, epigeneticExpand
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Continuous Cyclin E expression inhibits progression through endoreduplication cycles in Drosophila
Entry into S phase of the mitotic cell cycle is normally strictly dependent on progression through the preceding M phase. In contrast, during endoreduplication, which accompanies post-mitotic cellExpand
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Degradation of Drosophila PIM regulates sister chromatid separation during mitosis.
Drosophila Pimples (PIM) and Three rows (THR) are required for sister chromatid separation in mitosis. PIM accumulates during interphase and is degraded rapidly during mitosis. This degradation isExpand
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A screen for modifiers of cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2.
In higher eukaryotes, cyclin E is thought to control the progression from G1 into S phase of the cell cycle by associating as a regulatory subunit with cdk2. To identify genes interacting with cyclinExpand
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Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.
Sister-chromatid separation in mitosis requires proteolytic cleavage of a cohesin subunit. Separase, the corresponding protease, is activated at the metaphase-to-anaphase transition. ActivationExpand
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Structure Predictions and Interaction Studies Indicate Homology of Separase N-Terminal Regulatory Domains and Drosophila THR
The final resolution of sister chromatid cohesion during mitotic and meiotic divisions is mediated by activation of separase which cleaves a cohesin complex subunit. The structural basis of separaseExpand
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Bällchen is required for self-renewal of germline stem cells in Drosophila melanogaster
ABSTRACT Self-renewing stem cells are pools of undifferentiated cells, which are maintained in cellular niche environments by distinct tissue-specific signalling pathways. In Drosophila melanogaster,Expand
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Histone supply regulates S phase timing and cell cycle progression
Eukaryotes package DNA into nucleosomes that contain a core of histone proteins. During DNA replication, nucleosomes are disrupted and re-assembled with newly synthesized histones and DNA. DespiteExpand
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