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Robustness of Design Against Autocorrelation in Time I: Asymptotic Theory, Optimality for Location and Linear Regression
Optimum experimental designs for properties of a compartmental model.
Three properties of interest in bioavailability studies using compartmental models are the area under the concentration curve, the maximum concentration, and the time to maximum concentration.… Expand
Sudoku Squares and Chromatic Polynomials
T he Sudoku puzzle has become a very popular puzzle that many newspapers carry as a daily feature. Expand
The robustness and optimality of response surface designs
Abstract Recent work on extended optimality criteria for robust designs is applied to response surface problems. Methods of calculation are described and the criteria illustrated with several… Expand
Some Considerations in the Optimal Design of Experiments in Non‐Optimal Situations
Prognostic Variables for Survival in a Randomized Comparison of Treatments for Prostatic Cancer
These data were obtained from a randomized clinical trial comparing four treatments for patients with prostatic cancer in Stages 3 and 4. Stage 3 represents local extension of the disease without… Expand
Elemental information matrices and optimal experimental design for generalized regression models
The construction of optimal experimental designs for regression models requires knowledge of the information matrix of a single observation. The latter can be found if the elemental information… Expand
Incomplete factorial designs for randomized clinical trials.
Recently there has been increased interest in considering factorial designs for randomized clinical trials when one wishes to study two or more treatments. Such designs may offer impressive gains in… Expand