Nitrogen Control in Cyanobacteria
- A. Herrero, A. Muro-Pastor, E. Flores
- Biology, Environmental ScienceJournal of Bacteriology
- 15 January 2001
Nitrogen control in cyanobacteria is mediated by NtcA, a transcriptional regulator which belongs to the CAP (the catabolite gene activator or cyclic AMP [cAMP] receptor protein) family and is therefore different from the well-characterized Ntr system.
Molecular mechanism for the operation of nitrogen control in cyanobacteria.
In cyanobacteria, ammonium exerts a negative regulation of the expression of proteins involved in the assimilation of nitrogen sources alternative to ammonium. In Synechococcus, mRNA levels of genes…
Cellular differentiation and the NtcA transcription factor in filamentous cyanobacteria.
Compartmentalized function through cell differentiation in filamentous cyanobacteria
This Review addresses cyanob bacterial intercellular communication, the supracellular structure of the cyanobacterial filament and the basic principles that govern the process of heterocyst differentiation.
Nitrogen assimilation and nitrogen control in cyanobacteria.
The expression of many nitrogen assimilation genes is subjected to regulation being activated by the nitrogen-control transcription factor NtcA, which is autoregulatory and whose activity appears to be influenced by 2-oxoglutarate and the signal transduction protein P(II).
Mutual dependence of the expression of the cell differentiation regulatory protein HetR and the global nitrogen regulator NtcA during heterocyst development
A mutual dependency in the induction of the regulatory genes hetR and ntcA that takes place in response to nitrogen step‐down in Anabaena cells is indicated.
Assimilatory Nitrogen Metabolism and Its Regulation
A major theme for future research is how information about the N status of the cell is sensed and transduced to the protein(s) effecting regulation of gene expression, as paths of N assimilation in cyanobacteria are induced upon ammonium deprivation.
Photosynthetic nitrate assimilation in cyanobacteria
Despite significant advance in understanding the regulation of nitrate assimilation in cyanobacteria, further post-transcriptional regulatory mechanisms are likely to be discovered.
2‐Oxoglutarate increases the binding affinity of the NtcA (nitrogen control) transcription factor for the Synechococcus glnA promoter
Requirement of the regulatory protein NtcA for the expression of nitrogen assimilation and heterocyst development genes in the cyanobacterium Anabaena sp. PCC7120
Results showed that the ntcA gene product, NTCA, is required in Anabaena sp.