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STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
It is described that brain metastatic cells induce and maintain the co-option of a pro-metastatic program driven by signal transducer and activator of transcription 3 (STAT3) in a subpopulation of reactive astrocytes surrounding metastatic lesions, and that a safe and orally bioavailable treatment that inhibits STAT3 exhibits significant antitumor effects in patients with advanced systemic disease that included brain metastasis. Expand
The Added Value of Apparent Diffusion Coefficient to Cerebral Blood Volume in the Preoperative Grading of Diffuse Gliomas
Whether combined rCBV and ADC values improve the diagnostic accuracy of MR imaging in the preoperative grading of gliomas is studied by assessing 162 patients who later underwent surgery and found ADC measurements were better than r CBV values for distinguishing the grades ofgliomas. Expand
Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.
It is proposed that the recovery of EGFR stability is a key oncogenic event in a large proportion of gliomas and that pharmacological inhibition of DYRK1A could represent a promising therapeutic intervention for EGFR-dependent GBMs. Expand
A new muscle glycogen storage disease associated with glycogenin‐1 deficiency
It is indicated that either depletion of glycogenin‐1 or impaired interaction with glycogen synthase underlies this new form of glycogens storage disease that differs from a previously reported patient with GYG1 mutations who showed profound glycogen depletion in skeletal muscle and accumulation of glycagenin‐ 1. Expand
Preclinical Test of Dacomitinib, an Irreversible EGFR Inhibitor, Confirms Its Effectiveness for Glioblastoma
The data presented here confirm that dacomitinib clearly affects receptor signaling in vivo and that its strong antitumoral effect is independent of the presence of mutant receptor isoforms although it could be affected by the PTEN status (as it is less effective in a PTEN-deleted GBM line). Expand
The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas
The transcription of microtubule-associated protein TAU (MAPT), a gene that has been classically associated with neurodegenerative diseases, is epigenetically controlled by the balance between wt and mut IDH1/2 in mouse and human gliomas. Expand
Acute neurological deterioration as a result of two synchronous hemorrhagic spinal ependymomas
The first case of a patient with acute neurological deterioration as a consequence of synchronous bleeding of two spinal ependymomas located at different levels in the spinal cord is reported, illustrating the importance of recognizing the rare, but known occurrence of acute neurological deteriorated after spontaneous hemorrhage in spinal ependedymomas. Expand
De novo RYR1 heterozygous mutation (I4898T) causing lethal core-rod myopathy in twins.
"Core-rod myopathy" is a rare congenital myopathy characterized by the presence of "cores" and "rods" in distinct locations in the same or different muscle fibres. This association is linkedExpand
Phase II trial of dacomitinib, a pan–human EGFR tyrosine kinase inhibitor, in recurrent glioblastoma patients with EGFR amplification
Dacomitinib has a limited single-agent activity in recurrent glioblastoma with EGFR amplification and the detailed molecular characterization of the 4 patients with response in this trial can be useful to select patients who could benefit from dacomItinib. Expand