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The GPR54 Gene as a Regulator of Puberty
Background Puberty, a complex biologic process involving sexual development, accelerated linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone begins to be secretedExpand
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.
We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice and men for theExpand
The GPR54 gene as a regulator of puberty.
BACKGROUND Puberty, a complex biologic process involving sexual development, accelerated linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone begins to be secretedExpand
Synthetic chemerin-derived peptides suppress inflammation through ChemR23
Chemerin is a chemotactic protein that binds to the G protein–coupled receptor, ChemR23. We demonstrate that murine chemerin possesses potent antiinflammatory properties that are absolutely dependentExpand
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
N6-methyladenosine (m6A) is an abundant internal RNA modification in both coding and non-coding RNAs that is catalysed by the METTL3–METTL14 methyltransferase complex. However, the specific role ofExpand
Rab Coupling Protein (RCP), a Novel Rab4 and Rab11 Effector Protein*
Rab4 and Rab11 are small GTPases belonging to the Ras superfamily. They both function as regulators along the receptor recycling pathway. We have identified a novel 80-kDa protein that interactsExpand
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene
The G protein-coupled receptor GPR54 (AXOR12, OT7T175) is central to acquisition of reproductive competency in mammals. Peptide ligands (kisspeptins) for this receptor are encoded by the Kiss1 gene,Expand
Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.
We have recently identified Rab11-FIP4 as the sixth member of the Rab11-FIP family of Rab11 interacting proteins. Here, we demonstrate that Rab11-FIP4 interacts with Rab11 in a GTP-dependent mannerExpand
The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1.
Rab4 belongs to the Rab family of small GTPases involved in the regulation of intracellular transport, and has been localized to early endosomes. We have employed the yeast two-hybrid system toExpand
The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities.
The Rab11-FIP/Rip/RCP proteins are a recently described novel protein family, whose members interact with Rab GTPases that function in endosomal recycling. To date, five such proteins have beenExpand
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