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Systemic Absorption and Block after Epidural Injection of Ropivacaine in Healthy Volunteers
Background: For local anesthetics, the process of removal from the site of administration influences the duration of anesthesia and the risk for systemic toxicity to develop. The systemic absorption… Expand
The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans
- J. Persson, J. Hasselström, B. Wiklund, A. Heller, J. Svensson, L. Gustafsson
- Acta anaesthesiologica Scandinavica
- 1 August 1998
Background: Ketamine in sub‐dissociative doses has been shown to have analgesic and phantom‐Limb pain, where conventional treatment has often failed. Chronic ischemic pain due to lower extremity… Expand
Methamphetamine concentrations in fetal and maternal brain following prenatal exposure.
Levels of methamphetamine in maternal striatum and whole fetal mouse brain were assessed at 0.5, 1, 2, and 4 h postinjection on gestational day 14 (GD14) following a single, subcutaneous injection of… Expand
One-Lung Ventilation with High Tidal Volumes and Zero Positive End-Expiratory Pressure Is Injurious in the Isolated Rabbit Lung Model
- M. Gama de Abreu, Manuel Heintz, A. Heller, Roswitha Széchényi, D. M. Albrecht, T. Koch
- Anesthesia and analgesia
- 1 January 2003
We tested the hypothesis that one-lung ventilation (OLV) with high tidal volumes (Vt) and zero positive end-expiratory pressure (PEEP) may lead to ventilator-induced lung injury. In an isolated,… Expand
Measurement and modeling of the transient difference between blood and subcutaneous glucose concentrations in the rat after injection of insulin.
- D. W. Schmidtke, A. C. Freeland, A. Heller, R. Bonnecaze
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 6 January 1998
The kinetics of the fall in subcutaneous fluid glucose concentration in anesthetized rats (n = 7) after intravenous injection of insulin (0.5 units/kg) was studied by using 5 x 10(-4) cm2 active… Expand
Effects of intravenous anesthetics on bacterial elimination in human blood in vitro
- A. Heller, S. Heller, S. Blecken, R. Urbaschek, T. Koch
- Acta anaesthesiologica Scandinavica
- 1 May 1998
Backround: Since anesthetics are widely used in critically ill patients, this study investigates anesthetic effects on neutrophil and monocyte function concerning bacterial elimination in human whole… Expand
Alteration of n-3 fatty acid composition in lung tissue after short-term infusion of fish oil emulsion attenuates inflammatory vascular reaction.
OBJECTIVES To investigate whether modulation of the fatty acid profile can be achieved by the short-term infusion of a fish oil emulsion which may attenuate the pulmonary response to inflammatory… Expand
Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia.
OBJECTIVE The aim of this study was to investigate whether the methylxanthine-derivative pentoxifylline (PTX) affects bacterial clearance of the organism in states of hemorrhage and endotoxemia. … Expand
EFFECTS OF STROMA‐FREE HEMOGLOBIN SOLUTIONS ON PULMONARY VASCULAR RESISTANCE AND MEDIATOR RELEASE IN THE ISOLATED PERFUSED RABBIT LUNG
The aim of this study was to evaluate the effect of an ultrapure bovine stroma-free hemoglobin (SFH) on pulmonary vascular resistance and mediator release and to analyze potential mechanisms of… Expand
[Effects of human i.v. immunoglobulin on bacterial clearance and granulocyte function in endotoxinemia].
- T. Koch, S. Heller, K. Weber, A. Heller, R. Urbaschek
- Anasthesiologie, Intensivmedizin, Notfallmedizin…
- 1 July 1997
PURPOSE The therapeutic impact of intravenous immunoglobulins (ivIG) in septic patients remains controversial. Until now, the mechanisms of action have not been fully elucidated. Since… Expand