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Rate of de novo mutations and the importance of father’s age to disease risk
TLDR
A study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent–offspring trios at high coverage shows that the diversity in mutation rate of single nucleotide polymorphisms is dominated by the age of the father at conception of the child.
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Fine-scale recombination rate differences between sexes, populations and individuals
TLDR
This work constructs the first recombination maps based on directly observed recombinations with a resolution that is effective down to 10 kilobases (kb), and discovers novel associations between recombination characteristics of individuals and variants in the PRDM9 gene.
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Spread of SARS-CoV-2 in the Icelandic Population
TLDR
In a population-based study in Iceland, children under 10 years of age and females had a lower incidence of SARS-CoV-2 infection than adolescents or adults and males and the proportion of infected participants identified through population screening remained stable for the 20-day duration of screening.
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Humoral Immune Response to SARS-CoV-2 in Iceland
TLDR
The authors' results indicate that antiviral antibodies against SARS-CoV-2 did not decline within 4 months after diagnosis, and antiviral antibody titers assayed by two pan-Ig assays remained on a plateau for the remainder of the study.
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A direct characterization of human mutation based on microsatellites
TLDR
The largest study of new mutations to date, comprising 2,058 germline changes discovered by analyzing 85,289 Icelanders at 2,477 microsatellites, infer that the sequence mutation rate is 1.4–2.3 × 10−8 mutations per base pair per generation (90% credible interval) and that human-chimpanzee speciation occurred 3.7–6.6 million years ago.
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The mutation rate in the human mtDNA control region.
TLDR
The present study sequenced the mtDNA control region in 272 individuals, who were related by a total of 705 mtDNA transmission events, from 26 large Icelandic pedigrees, and the estimated mutation rate is intermediate among those derived from pedigree-based studies.
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The nature of nurture: Effects of parental genotypes
TLDR
The findings suggest that genetic nurture is ultimately due to genetic variation in the population and is mediated by the environment that parents create for their children.
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mtDna and the islands of the North Atlantic: estimating the proportions of Norse and Gaelic ancestry.
TLDR
Admixture analyses indicate that the ancestral contributions of mtDNA lineages from Scandinavia to the populations of Iceland, Orkney, the Western Isles, and the Isle of Skye are 37.5%, 35.
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Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.
TLDR
It is found that CH is very common in the elderly, trending toward inevitability, and somatic mutations in TET2, DNMT3A, ASXL1, and PPM1D are associated with CH at high significance, however, known CD mutations were evident in only a fraction of CH cases.
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Parental influence on human germline de novo mutations in 1,548 trios from Iceland
TLDR
Increased sequence diversity and linkage disequilibrium of C>G variants within regions affected by excess maternal mutations indicate that the underlying mutational process has persisted in humans for thousands of years.
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