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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
We show that loss of Apc acutely activates Wnt signaling through the nuclear accumulation of beta-catenin, which perturbs differentiation, migration, proliferation, and apoptosis. Expand
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Extracellular matrix in development of the intervertebral disc.
Intervertebral discs allow bending and twisting of the spine whilst resisting compression from gravity and muscle action, and are composite structures of the peripheral annulus fibrosus enclosing theExpand
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The development of articular cartilage: evidence for an appositional growth mechanism
It is well-established that cartilage grows by a combination of matrix secretion, cell hypertrophy and cell proliferation. The extent to which this growth is by appositional, as opposed toExpand
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Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis1
Cytokine control of the synovial infiltrate is a central process in the development of inflammatory arthritis. In this study, we combine genetic approaches and intervention strategies to describe aExpand
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Macromolecular Organization and In Vitro Growth Characteristics of Scaffold-free Neocartilage Grafts
Recent advances in tissue engineering offer considerable promise for the repair of focal lesions in articular cartilage. Here we describe (1) the macromolecular organization of tissue-engineeredExpand
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The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-β1 and IGF-1
The annulus fibrosus of the intervertebral disc is a complex radial-ply tissue that derives initially from segmental condensations of axial mesenchyme surrounding the notochord. These mesenchymalExpand
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Vigour, vitality and viability of microorganisms
Assessment of the vigour, vitality or viability of microorganisms must be done on an individual basis and thus requires the non-invasive interrogation of single organisms. For suspended organisms,Expand
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Role of actin stress fibres in the development of the intervertebral disc: Cytoskeletal control of extracellular matrix assembly
Orientation of collagen fibrils is a key event in the development of many tissues. In the intervertebral disc, the outer annulus fibrosus comprises lamellae of parallel collagen fibres, the directionExpand
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Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc
BackgroundThe intervertebral disc (IVD) is a complex cartilaginous structure which functions to resist biomechanical loads during spinal movement. It consists of the highly viscous cartilaginousExpand
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A passive sampler for hydrogen sulfide
The silver nitrate/fluorescein mercuric acetate fluorimetric method for the measurement of atmospheric hydrogen sulfide has been adapted to passive sampling. Standard samplers have been tested andExpand
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