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Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
TLDR
Individuals prescribed an antibiotic in primary care for a respiratory or urinary infection develop bacterial resistance to that antibiotic, which not only increases the population carriage of organisms resistant to first line antibiotics, but also creates the conditions for increased use of second line antibiotics in the community.
Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and
TLDR
Prevalence of resistance to commonly prescribed antibiotics in primary care in children with urinary tract infections caused by E coli is high, particularly in countries outside the OECD, where one possible explanation is the availability of antibiotics over the counter.
Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
TLDR
Parents, nurses, pharmacists, and doctors wanting to use medicines to supplement physical measures to maximise the time that children spend without fever should use ibuprofen first and consider the relative benefits and risks of using paracetamol plus ib uprofen over 24 hours.
Parents’ information needs, self-efficacy and influences on consulting for childhood respiratory tract infections: a qualitative study
TLDR
The perception of threat to a child of RTI (with cough) was increased with more severe illness and by perceived susceptibility to illness of a particular child; whilst experience with other children increased parental efficacy to cope with childhood cough at home.
The science of clinical practice: disease diagnosis or patient prognosis? Evidence about “what is likely to happen” should shape clinical practice
TLDR
Patient prognosis can provide the framework for modern clinical practice to integrate information from the expanding biological, social, and clinical database for more effective and efficient care.
Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial.
TLDR
Paracetamol and ibuprofen together was the cheapest option for the NHS due to the lower use of health-care services and cheapest for parents because the lowerUse of health care services resulted in personal saving on travel costs and less time off work.
Potential for reducing inappropriate antibiotic prescribing in English primary care
TLDR
The existence of substantial inappropriate antibiotic prescribing and poor diagnostic coding in English primary care is demonstrated and all practices (not just the high prescribers) should engage in efforts to improve antimicrobial stewardship.
Safety of reduced antibiotic prescribing for self limiting respiratory tract infections in primary care: cohort study using electronic health records
TLDR
Even a substantial reduction in antibiotic prescribing was predicted to be associated with only a small increase in numbers of cases observed overall, but caution might be required in subgroups at higher risk of pneumonia.
The prevalence of symptoms and consultations in pre-school children in the Avon Longitudinal Study of Parents and Children (ALSPAC): a prospective cohort study.
TLDR
Research of acute conditions in young children could focus on the most common symptoms leading to consultation, namely cough, fever and earache, which are a normal part of pre-school life.
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