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Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases
Mendelian randomization (MR) is a widely-used method for causal inference using genetic data. Mendelian randomization studies of unrelated individuals may be susceptible to bias from familyExpand
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Clinical Features of Children With Autism Who Passed 18-Month Screening
This is the first study in which researchers examine developmental and temperamental characteristics of boys and girls screening negative for autism at 18 months. OBJECTIVES: We comparedExpand
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Association of Maternal Neurodevelopmental Risk Alleles With Early-Life Exposures
Key Points Question Are maternal polygenic risk scores for neurodevelopmental disorders associated with early-life exposures? Findings In this population-based cohort study of 7921 mothers, polygenicExpand
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Investigating causality in the association between vitamin D status and self-reported tiredness
Self-reported tiredness or low energy, often referred to as fatigue, has been linked to low levels of circulating 25-hydroxyvitamin D (25OHD), a biomarker of vitamin D status. Although it isExpand
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Within family Mendelian randomization studies.
Mendelian randomization (MR) is increasingly used to make causal inferences in a wide range of fields, from drug development to aetiologic studies. Causal inference in MR is possible because of theExpand
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Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family MendelianExpand
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Genetic Association Study of Childhood Aggression across raters, instruments and age
Background Human aggressive behavior (AGG) has a substantial genetic component. Here we present a large genome-wide association meta-analysis (GWAMA) of childhood AGG. Methods We analyzed assessmentsExpand
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Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood
Background: There is a wealth of literature on the observed association between childhood trauma and psychotic illness. However, the relationship between childhood trauma and psychosis is complex andExpand
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Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study.
BACKGROUND Low educational attainment in parents is associated with child psychopathology. It is not clear whether the associations are due to risk factors that family members share or due to effectsExpand
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