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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genomeExpand
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The database of experimentally supported targets: a functional update of TarBase
TLDR
TarBase5.0 is a database which houses a manually curated collection of experimentally supported microRNA targets in several animal species of central scientific interest. Expand
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TarBase: A comprehensive database of experimentally supported animal microRNA targets.
MicroRNAs (miRNAs) are approximately 22-nt RNA segments that are involved in the regulation of protein expression primarily by binding to one or more target sites on an mRNA transcript and inhibitingExpand
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DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions
TLDR
We provide for the first time hundreds of thousands of high-quality manually curated experimentally validated miRNA:gene interactions, enhanced with detailed meta-data. Expand
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TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support
TLDR
TarBase 6.0 hosts the largest collection of manually curated experimentally validated miRNA–gene interactions (more than 65 000 targets), presenting a 16.5–175-fold increase over other available manually curated databases. Expand
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A combined computational-experimental approach predicts human microRNA targets.
A new paradigm of gene expression regulation has emerged recently with the discovery of microRNAs (miRNAs). Most, if not all, miRNAs are thought to control gene expression, mostly by base pairingExpand
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DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows
TLDR
In silico-predicted miRNA–gene interactions in Homo sapiens, Mus musculus, and Caenorhabditis elegans . Expand
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microRNAs exhibit high frequency genomic alterations in human cancer.
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene expression. To determine genomewide miRNA DNA copy number abnormalities in cancer, 283 known human miRNA genes wereExpand
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DIANA-microT web server: elucidating microRNA functions through target prediction
TLDR
The DIANA-microT web server provides extensive information for predicted miRNA:target gene interactions with a user-friendly interface, providing extensive connectivity to online biological resources. Expand
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Redirection of Silencing Targets by Adenosine-to-Inosine Editing of miRNAs
Primary transcripts of certain microRNA (miRNA) genes are subject to RNA editing that converts adenosine to inosine. However, the importance of miRNA editing remains largely undetermined. Here weExpand
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