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An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides
TLDR
This work purified from liver microsomes a lumenal, soluble aminopeptidase that removes NH2-terminal residues from many antigenic precursors that stimulates the processing and presentation of an antigenic precursor in the ER. Expand
The oxytocinase subfamily of M1 aminopeptidases.
TLDR
It is getting evident that the subfamily members play important roles in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. Expand
Human Leukocyte-derived Arginine Aminopeptidase
TLDR
Results indicate that L-RAP is a novel aminopeptidase that can trim the N-terminal extended precursors to antigenic peptides in the endoplasmic reticulum. Expand
Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme
TLDR
Cell-based Ag-presentation analysis was consistent with changes in the substrate inhibition constant Ki, supporting that ERAP1 allelic composition may affect Ag processing in vivo and proposing that these phenomena should be taken into account when evaluating the possible link between Ag processing and autoimmunity. Expand
Reduced activity of the hypertension‐associated Lys528Arg mutant of human adipocyte‐derived leucine aminopeptidase (A‐LAP)/ER‐aminopeptidase‐1
TLDR
It is suggested that Lys528 is important for maximal activity of A‐LAP by maintaining the appropriate structure of the substrate pocket of the enzyme. Expand
Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells.
TLDR
Results indicate that A-LAP possesses a broad substrate specificity towards naturally occurring peptide hormones and suggest that it plays a role in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Expand
Distribution and Characterization of Specific Cellular Binding Proteins for Bone Morphogenetic Protein-2 (*)
TLDR
Examination of the distribution of the specific cellular binding proteins for BMP-2 on a wide variety of cell types suggests that major types of cells other than hematopoietic cells and vascular endothelial cells may be potential targets for B MP-2 action. Expand
Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase.
TLDR
The identification of A-LAP, which reveals strong homology to P- LAP, might lead to the definition of a new subfamily of zinc-containing aminopeptidases belonging to the M1 family of metallopeptIDases. Expand
Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells.
TLDR
An initial biochemical and enzymatic characterization of moleculary defined P-LAP/oxytocinase is provided and it was shown that the enzyme has broad specificity and is inhibited by several compounds known as aminopeptidase inhibitors. Expand
The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response.
TLDR
The results indicate that LAP2 is indeed an enzymatically active aminopeptidase and plays key roles in senescence, stress response and amino acid turnover and integration of global gene expression and metabolite analyses suggest that Lap2 controlled intracellular amino acids turnover. Expand
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