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SMAD proteins control DROSHA-mediated microRNA maturation
MicroRNAs (miRNAs) are small non-coding RNAs that participate in the spatiotemporal regulation of messenger RNA and protein synthesis. Aberrant miRNA expression leads to developmental abnormalitiesExpand
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A human Mad protein acting as a BMP-regulated transcriptional activator
THE TGF-β/activin/BMP cytokine family signals through serine/threonine kinase receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against decapentaplegic) gene fromExpand
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Targeting the TGFβ signalling pathway in disease
Many drugs that target transforming growth factor-β (TGFβ) signalling have been developed, some of which have reached Phase III clinical trials for a number of disease applications. Preclinical andExpand
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Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism.
A mouse model of Rubinstein-Taybi syndrome (RTS) was generated by an insertional mutation into the cyclic AMP response element-binding protein (CREB)-binding protein (CBP) gene. HeterozygousExpand
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A structural basis for mutational inactivation of the tumour suppressor Smad4
The Smad4/DPC4 tumour suppressor is inactivated in nearly half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. Smad4/DPC4, and the related tumour suppressor Smad2,Expand
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OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways
We have identified the 30-zinc finger protein OAZ as a DNA-binding factor that associates with Smads in response to BMP2, forming a complex that transcriptionally activates the homeobox regulator ofExpand
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Tyrosine kinases Lyn and Syk regulate B cell receptor‐coupled Ca2+ mobilization through distinct pathways.
Stimulation of B lymphocytes through their antigen receptor (BCR) results in rapid increases in tyrosine phosphorylation on a number of proteins and induces both an increase of phosphatidylinositolExpand
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Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
THE TGF-β/activin/BMP superfamily of growth factors signals through heteromeric receptor complexes of type I and type II serine/threonine kinase receptors1. The signal originated by TGF-β-likeExpand
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Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
Smad2 and Smad4 are related tumour-suppressor proteins, which, when stimulated by the growth factor TGF-β, form a complex to inhibit growth. The effector function of Smad2 and Smad4 is located in theExpand
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Title Targeting the TGFβ signalling pathway in disease
| Many drugs that target transforming growth factor-β (TGFβ) signalling have disease applications. Preclinical and clinical studies indicate the utility of these agents in fibrosis and oncology,Expand
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