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Functional Comparison of d‐Serine and Glycine in Rodents: The Effect on Cloned NMDA Receptors and the Extracellular Concentration
TLDR
D‐Ser is a candidate of the endogenous potentiator of the NMDA receptor in the rodent frontal cortex and this result showed that the residues play crucial roles in the action of d‐Ser. Expand
Embryonic Development and Postnatal Changes in Free d‐Aspartate and d‐Serine in the Human Prefrontal Cortex
TLDR
The present data suggest that d‐aspartate and d‐serine might play a pivotal role in cerebral development and functions that are related to the NMDA receptor. Expand
Free d-serine, d-aspartate and d-alanine in central nervous system and serum in mutant mice lacking d-amino acid oxidase
TLDR
It is found that the content of D-serine in the serum and cerebellum of mutant mice is much higher than that of normal mice, whereas a slight but significant difference in the cerebral D-Serine level is observed between the two strains. Expand
Free d-aspartate and d-serine in the mammalian brain and periphery
TLDR
This review deals with the recent advances in the studies of presence of free D-aspartate and D-serine and their metabolic systems in mammals and shall discuss also the NMDA receptor and uptake system of D-amino acids. Expand
The presence of free D‐serine in rat brain
TLDR
These data provide the first evidence that substantial quantities of free D‐serine are present in mammalian brain tissues, and a peak X, which exhibited the same retention time as the N,O‐pentafluoropropionyl isopropyl derivative of authentic D‐Serine, was detected in the brain extracts. Expand
Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems.
TLDR
Interestingly, oleamide analogs resistant to hydrolysis by fatty acid amide hydrolase (FAAH) maintained but did not show increased behavioral potency or duration of action, whereas two FAAH inhibitors produced analogous behavioral effects. Expand
Free d-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases
TLDR
Findings add further support to the view that D-serine could be an intrinsic modulator of the NMDA receptor liberated from certain glial cells in the mammalian brain. Expand
Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat.
TLDR
D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia. Expand
Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.
TLDR
A unique mechanism by which sulfhydration of one subunit modifies tyrosine nitration of another subunit within the same channel complex is demonstrated, providing a mechanistic insight on the protective effects of H₂S in inflammation. Expand
Differential effects of phencyclidine and methamphetamine on dopamine metabolism in rat frontal cortex and striatum as revealed by in vivo dialysis
TLDR
The present results clearly demonstrate the differential effects of PCP on cortical and striatalDA transmission, suggesting that PCP may facilitate DA release in the medial frontal cortex by increasing impulse flow in the DA neurons projecting to the cortical area, whereas PCP‐induced elevation of extracellular DA in the striatum may be caused mainly by reuptake inhibition of DA liberated by basal activity of the striatal DA neurons. Expand
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