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Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth
  • A. Hasbi, T. Fan, S. George
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences
  • 15 December 2009
TLDR
The exclusive stimulation of the dopamine D1–D2 receptor heteromer led to the activation of a signaling cascade that links dopamine signaling to BDNF production and neuronal growth through a cascade of four steps, which may have considerable significance in disorders such as drug addiction, schizophrenia, and depression.
The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons
The distribution and function of neurons coexpressing the dopamine D1 and D2 receptors in the basal ganglia and mesolimbic system are unknown. We found a subset of medium spiny neurons coexpressing
Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance
TLDR
The emerging neurobiology of the known dopamine receptor heteromers, their physiological relevance in brain, and the potential role of these receptor complexes in neuropsychiatric disease are described.
The Dopamine D1–D2 Receptor Heteromer in Striatal Medium Spiny Neurons: Evidence for a Third Distinct Neuronal Pathway in Basal Ganglia
TLDR
Evidence in support of a novel third pathway coexpressing the D1 and D2 receptor is discussed and the potential relevance of this pathway to basal ganglia signaling is discussed, to address its potential value and that of the dopamine D1–D2 receptor heteromer, in the search for new therapeutic strategies for disorders involving dopamine neurotransmission.
Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists.
The cellular site of formation, Galpha-coupling preference, and agonist regulation of mu-delta opioid receptor (OR) heterooligomers were studied. Bioluminescence resonance energy transfer (BRET)
Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
TLDR
This work has shown that the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown.
Regulation of D1 Dopamine Receptor Trafficking and Signaling by Caveolin-1
TLDR
It is determined that the D1 dopamine receptor (D1R) is localized in caveolae, a subset of lipid rafts, by sucrose gradient fractionation and confocal microscopy and this data suggest that Caveolae has an important role in regulating D1R turnover and signaling in brain.
Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2.
TLDR
The dynamics of agonist-induced interactions of a GRK with a G protein-coupled receptor in real time is demonstrated for the first time, using time-resolved bioluminescence resonance energy transfer, and GRK/OTR interaction is established as a prerequisite for beta-arrestin-mediated OTR desensitization.
A peptide targeting an interaction interface disrupts the dopamine D1‐D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism
TLDR
A peptide targeting an interaction interface disrupts the dopamine D1‐D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism revealed a pathophysiological role for the D1-D2 heteromer in the modulation of behavioral despair.
Trafficking of preassembled opioid μ-δ heterooligomer-Gz signaling complexes to the plasma membrane: Coregulation by agonists
The cellular site of formation, Galpha-coupling preference, and agonist regulation of mu-delta opioid receptor (OR) heterooligomers were studied. Bioluminescence resonance energy transfer (BRET)
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