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Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.
The expression pattern of human sialoadhesin was found to be similar to that of the mouse receptor, being absent from monocytes and other peripheral blood leukocytes, but expressed strongly by tissue macrophages in the spleen, lymph node, bone marrow, liver, colon, and lungs. Expand
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors
LTB4 was highly chemotactic for 2-wk-old cells, but not mature cells, correlating with a loss of mRNA for the LTB4 receptor, BLT1, and was a potent chemoattractant for human cord blood–derived immature, butNot mature, mast cells. Expand
CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines.
CD69 can be used as a marker of eosinophil activation by cytokines and is a candidate receptor for triggering eos inophil mediator release in the airways in asthma. Expand
Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.
The observed up-regulation of MIP-1alpha signaling via non-CCR3 pathways may play a role in eosinophil recruitment in inflammatory states such as occurs in the asthmatic lung. Expand
Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness.
The hypothesis that selective activation of memory CD4 T cells contributes to eosinophil accumulation, bronchial hyperresponsiveness, and symptoms in asthma is supported. Expand
Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily
It is demonstrated that a subgroup of the immunoglobulin superfamily can mediate diverse biological processes through recognition of specific sialylated glycans on cell surfaces through binding to cell-surface glycans that contain sialic acid. Expand
The species‐specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin‐positive macrophages occur in the perifollicular zone, but not in the marginal zone
The microanatomical structure of human and rat splenic white pulp is compared, with special emphasis on the localization of the marginal zone occupied by immunoglobulin M (IgM)+ IgD−/dull BExpand
Expression of mRNA and immunoreactivity for the granulocyte/macrophage colony-stimulating factor in activated human eosinophils
The identification of GM-CSF production by human eosinophils suggests that the pro-inflammatory potential of this cell type may be substantially greater than hitherto recognized. Expand
Fc gamma and CD11/CD18 receptor expression on normal density and low density human eosinophils.
The findings emphasize the unique phenotype of the human eosinophil in terms of Fc gamma receptor expression, the similarity of the eosInophil and neutrophil with regard to the leucocyte integrins and that eos inophils of low density do not differ greatly from those of normal density in termsof receptor expression. Expand
Chemotactic action of prostaglandin E2 on mouse mast cells acting via the PGE2 receptor 3
Results show an unexpected function for PGE2 in the chemotaxis of mast cells, which is a highly potent chemoattractant for immature and mature mast cells in vitro. Expand