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Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
IMPORTANCE Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatricExpand
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Psychopharmacology of theobromine in healthy volunteers
BackgroundTheobromine, a methylxanthine related to caffeine and present in high levels in cocoa, may contribute to the appeal of chocolate. However, current evidence for this is limited.ObjectivesWeExpand
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Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium
Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variantsExpand
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Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
  • A. Hart, H. Kranzler
  • Biology, Medicine
  • Alcoholism, clinical and experimental research
  • 1 August 2015
BACKGROUND Alcohol dependence (AD) is a complex psychiatric disorder and a significant public health problem. Twin and family-based studies have consistently estimated its heritability to beExpand
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Genetic factors modulating the response to stimulant drugs in humans.
Individuals vary in their responses to stimulant drugs, and several lines of evidence suggest that the basis for this variation is at least partially genetic in origin. Association studies haveExpand
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Candidate Gene Studies of a Promising Intermediate Phenotype: Failure to Replicate
Many candidate gene studies use ‘intermediate phenotypes’ instead of disease diagnoses. It has been proposed that intermediate phenotypes have simpler genetic architectures such that individualExpand
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Genome-Wide Association Study of d-Amphetamine Response in Healthy Volunteers Identifies Putative Associations, Including Cadherin 13 (CDH13)
Both the subjective response to d-amphetamine and the risk for amphetamine addiction are known to be heritable traits. Because subjective responses to drugs may predict drug addiction, identifyingExpand
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Does COMT genotype influence the effects of d‐amphetamine on executive functioning?
In a widely cited study, Mattay et al. reported that amphetamine (0.25 mg/kg oral, or 17 mg for a 68 kg individual) impaired behavioral and brain indices of executive functioning, measured using theExpand
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Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation
Loneliness is a complex biological trait that has been associated with numerous negative health outcomes. The measurement and environmental determinants of loneliness are well understood, but itsExpand
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Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?
Although alcohol dependence (AD) is approximately 50% heritable, little is known about how specific genetic loci affect AD risk. In a genome‐wide association study (GWAS), we identified highlyExpand
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