• Publications
  • Influence
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
The sterol regulatory element binding protein (SREBP) family of transcription activators are critical regulators of cholesterol and fatty acid homeostasis. We previously demonstrated that humanExpand
  • 317
  • 33
  • PDF
Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor
How does the nervous system encode environmental stimuli as sensory experiences? Both the type (visual, olfactory, gustatory, mechanical or auditory) and the quality of a stimulus (spatial position,Expand
  • 382
  • 33
Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species
Neuropeptides play critical roles in synaptic signaling in all nervous systems. Unlike classical neurotransmitters, peptidergic neurotransmitters are encoded as preproproteins that areExpand
  • 308
  • 28
  • PDF
A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans
Sterol regulatory element-binding proteins (SREBPs) activate genes involved in the synthesis and trafficking of cholesterol and other lipids and are critical for maintaining lipid homeostasis.Expand
  • 245
  • 27
  • PDF
Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.
Serotonin (5-HT) modulates synaptic efficacy in the nervous system of vertebrates and invertebrates. In the nematode Caenorhabditis elegans, many behaviors are regulated by 5-HT levels, which are inExpand
  • 206
  • 25
Optical interrogation of neural circuits in Caenorhabditis elegans
The nematode Caenorhabditis elegans has a compact nervous system with only 302 neurons. Whereas most of the synaptic connections between these neurons have been identified by electron microscopyExpand
  • 194
  • 21
  • PDF
Modeling Spinal Muscular Atrophy in Drosophila
Spinal Muscular Atrophy (SMA), a recessive hereditary neurodegenerative disease in humans, has been linked to mutations in the survival motor neuron (SMN) gene. SMA patients display early onsetExpand
  • 164
  • 20
  • PDF
Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
Huntington's disease (HD) is an incurable neurodegenerative disease caused by neuronal accumulation of the mutant protein huntingtin. Improving clearance of the mutant protein is expected to preventExpand
  • 358
  • 18
  • PDF
Distinct Signaling Pathways Mediate Touch and Osmosensory Responses in a Polymodal Sensory Neuron
The Caenorhabditis elegans ASH sensory neurons mediate responses to nose touch, hyperosmolarity, and volatile repellent chemicals. We show here that distinct signaling pathways mediate the responsesExpand
  • 146
  • 16
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in theExpand
  • 261
  • 12
  • PDF