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5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
Morphometrical analyses showed reduced gray matter volume in short-allele carriers in limbic regions critical for processing of negative emotion, particularly perigenual cingulate and amygdala, and relative uncoupling of this circuit.
Serotonin Transporter Genetic Variation and the Response of the Human Amygdala
Genetically driven variation in the response of brain regions underlying human emotional behavior is demonstrated and differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele.
Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits
The authors evaluate four lines of evidence about the 5-HTT stress-sensitivity hypothesis: observational studies about the serotonin transporter linked polymorphic region (5-HTTLPR), stress sensitivity, and depression in humans, research about one of the most extensive areas of inquiry.
Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance
The relationship of the BDNF val66met genotype and hippocampal activity during episodic memory processing using blood oxygenation level-dependent functional magnetic resonance imaging and a declarative memory task in healthy individuals suggests that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans.
Modulating emotional responses: effects of a neocortical network on the limbic system
Functional MRI results provide evidence for a network in which higher regions attenuate emotional responses at the most fundamental levels in the brain and suggest a neural basis for modulating emotional experience through interpretation and labeling.
Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
- V. Mattay, T. Goldberg, D. Weinberger
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 25 April 2003
Basic evidence of an inverted-“U” functional-response curve to increasing dopamine signaling in the prefrontal cortex is extended and individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine.
Neurophysiological correlates of age-related changes in human motor function
It is shown that elderly subjects recruit additional cortical and subcortical areas even for the performance of a simple motor task, which may represent compensatory mechanisms invoked by the aging brain, such as reorganization and redistribution of functional networks to compensate for age-related structural and neurochemical changes.
The Amygdala Response to Emotional Stimuli: A Comparison of Faces and Scenes
- A. Hariri, A. Tessitore, V. Mattay, F. Fera, D. Weinberger
- Psychology, BiologyNeuroImage
- 1 September 2002
Results suggest that the human amygdala shows a stronger response to affective facial expressions than to scenes, a bias that should be considered in the design of experimental paradigms interested in probing amygdala function.
A susceptibility gene for affective disorders and the response of the human amygdala.
- A. Hariri, E. Drabant, D. Weinberger
- Psychology, BiologyArchives of general psychiatry
- 1 February 2005
A potent modulatory effect of the 5-HTTLPR on amygdala reactivity to environmental threat is revealed, which may represent a classic susceptibility factor for affective disorders by biasing the functional reactivity of the human amygdala in the context of stressful life experiences and/or deficient cortical regulatory input.
Is there a general factor of prevalent psychopathology during adulthood?
- B. Lahey, B. Applegate, J. Hakes, D. Zald, A. Hariri, P. Rathouz
- PsychologyJournal of abnormal psychology
- 30 July 2012
The hypothesis that these prevalent forms of psychopathology have both important common and unique features is supported, which is whether this is because they share elements of their etiology and neurobiological mechanisms.