A. Hara

Publications363
h-index42
Citations8,911
Highly Influential Citations334
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Lipid extraction of tissues with a low-toxicity solvent.
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Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver.
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Multiplicity of mammalian reductases for xenobiotic carbonyl compounds.
TLDR
Accumulating data on the human enzymes provide new insights into their roles in cellular and molecular reactions including xenobiotic metabolism, as well as suggesting their involvement in species-specific biological events and species differences in the metabolism of Xenobiotic carbonyl compounds.
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Molecular Characterization of Mammalian Dicarbonyl/l-Xylulose Reductase and Its Localization in Kidney*
TLDR
The results imply that P34H and diacetyl reductase are identical tol-xylulose reduct enzyme, which is involved in the uronate cycle of glucose metabolism, and the unique localization of the enzyme in kidney suggests that it has a role other than in general carbohydrate metabolism.
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Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family.
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Phylogenetic and structural analyses of the mating-type loci in Clavicipitaceae.
TLDR
Entomopathogens and other econutritional fungi belonging to Clavicipitaceae were phylogenetically analyzed on the basis of the 18S rRNA gene and mating-type genes and the deletion of MAT1-1-3 was supposed to have occurred once in Clav anticipitaceae, and a good indication for the evolution of Clav anticipateitaceae.
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Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
TLDR
The results suggest that AKR1C3 acts as prostaglandin D2 11-ketoreductase, and that its principal gene in the human has a coding region represented by DBDH cDNA.
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Molecular Cloning and Characterization of Mouse Estradiol 17-Dehydrogenase (A-Specific), a Member of the Aldoketoreductase Family (*)
TLDR
The expression of the cDNA in Escherichia coli resulted in synthesis of a protein that was active toward androgens, estrogens, and xenobiotic substrates, and the mouse enzyme was given the designation of estradiol 17β-dehydrogenase (A-specific).
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Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids.
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SDR Structure, Mechanism of Action, and Substrate Recognition
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