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GRIM-19, a Cell Death Regulatory Protein, Is Essential for Assembly and Function of Mitochondrial Complex I
ABSTRACT Mitochondria play essential roles in cellular energy production via the oxidative phosphorylation system (OXPHOS) consisting of five multiprotein complexes and also in the initiation ofExpand
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Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia
BackgroundHypoxia induces microglial activation which causes damage to the developing brain. Microglia derived inflammatory mediators may contribute to this process. Toll-like receptor 4 (TLR4) hasExpand
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Expression profile of embryonic stem cell‐associated genes Oct4, Sox2 and Nanog in human gliomas
Guo Y, Liu S, Wang P, Zhao S, Wang F, Bing L, Zhang Y, Ling E‐A, Gao J & Hao A
(2011) Histopathology59, 763–775
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Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma
The POU family transcription factor OCT4 is required for maintaining the pluripotency of embryonic stem cells and for generating induced pluripotent stem cells. Although OCT4 is clearly shown to beExpand
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Melatonin inhibits tumorigenicity of glioblastoma stem‐like cells via the AKT–EZH2–STAT3 signaling axis
Glioblastoma stem‐like cells (GSCs) displaying self‐renewing and tumor‐propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumorExpand
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Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine.
  • Ting Wang, N. Wang, +4 authors Tiefu Li
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 18 September 2011
To enhance oral bioavailability and anti-diabetic efficacy of berberine (BER), an anhydrous reverse micelle (ARM) delivery system was prepared through lyophilization of water-in-oil (W/O) emulsions.Expand
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Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells
Abstract:  Melatonin, an indolamine produced and secreted predominately by the pineal gland, exhibits a variety of physiological functions, possesses antioxidant and antitumor properties. In thisExpand
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Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro.
Bone marrow mesenchymal stem cells (MSCs) have been shown great potential for cardiac regeneration. However the therapeutic efficiency has become a major obstacle due to the poor survival ofExpand
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Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase.
Elevated plasma free fatty acid (FFA) level is common in many pathological conditions, including neurological disorders, and their deleterious effects on various cells have been well documented.Expand
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Oxidative stress mediates hippocampal neuron death in rats after lithium–pilocarpine-induced status epilepticus
Oxidative stress, which is defined as the over-production of free radicals, can dramatically alter neuronal function and has been linked to status epilepticus (SE). The pathological process andExpand
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