• Publications
  • Influence
Clear cell adenocarcinoma of the vagina and cervix
The objective of this study was to update the registry of women in the Netherlands with clear cell adenocarcinoma (CCAC) of the cervix or vagina with or without intrauterine exposure to
Hue-saturation-density (HSD) model for stain recognition in digital images from transmitted light microscopy.
TLDR
The newly derived HSD model was found superior to the existing models for stain recognition in transmitted light microscopy, and enabled all possible distinctions in a two-dimensional, standardised data space.
A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine.
TLDR
Successful application of CARD-ISH with locus-specific DNA probes on histological and cytological samples may improve the determination of structural chromosomal aberrations in archival material.
Liquid‐based cervical cytology
The objective of the current study was to evaluate the applicability of liquid‐based cytology in the Netherlands population screening program for cervical cancer.
Changes in expression of differentiation markers between normal ovarian cells and derived tumors.
TLDR
The marker profile of 18 samples of normal human ovarian tissues and 138 samples of their derived tumors was established and TAG-72 appeared useful for its discrimination between positively stained mucinous adenomas, the ovarian carcinomas as well as germ cell tumors, and the negatively stained gonadal tumors, serous adanomas, and cystomas.
AgarCyto: A Novel Cell-processing Method for Multiple Molecular Diagnostic Analyses of the Uterine Cervix
TLDR
The AgarCyto cell block protocol is an excellent tool for inventory studies of diagnostic and potentially prognostic molecular markers of cervical cancer and includes an option for DNA image cytometry.
Proliferation in "atypical" atrophic pap smears.
TLDR
Measurement of PAI in MIB1 restained Pap smear is a simple, reliable, safe, and probably also cost-effective method to obtain a substantial reduction of diagnostic estrogen courses and subsequent Pap smears in postmenopausal women with an atypical Pap smear.
Criteria for Organized Cervical Screening Programs
TLDR
Conditions for efficient and effective population screening for cervical cancer are described and recommended to determine if these criteria are met and to give recommendations for improvement.
Endocervical status is not predictive of the incidence of cervical cancer in the years after negative smears.
TLDR
There is no reason to advise women with negative smears without endocervical cells to undergo an additional smear, and the proportion of women in whom invasive cancer developed was the same in both groups.
Metaanalysis of the accuracy of rapid prescreening relative to full screening of pap smears
TLDR
This study pooled data on the diagnostic quality of rapid reviewing of cervical smears initially reported as normal or unsatisfactory to focus on rapid prescreening (RPS) of unreported smears.
...
...