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Enriched environments, experience-dependent plasticity and disorders of the nervous system
TLDR
Findings on the environmental modulators of pathogenesis and gene–environment interactions in CNS disorders, and their therapeutic implications, are reviewed. Expand
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type
TLDR
The discovery that several available lines of HD mice faithfully recapitulate the gene expression signature of the human disorder provides a novel aspect of validation with respect to their use in preclinical therapeutic trials. Expand
Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism
TLDR
The results suggest that environmental enrichment benefits animals at early stages of the disease by rescuing protein deficits, possibly through rescuing transcription or protein transport problems. Expand
Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in huntington’s disease transgenic mice
TLDR
It is shown that voluntary physical exercise delays the onset of Huntington's disease and the decline in cognitive ability, and some aspects of hippocampal dependent memory are not entirely reliant on sustained hippocampal brain-derived neurotrophic factor expression. Expand
Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment
TLDR
The results suggest that decreased neurogenesis might be responsible, in part, for the hippocampal deficits observed in these mice and that environmental enrichment produces morphological changes in newborn granule neurons in both wild‐type and R6/1 mice, which could underlie some of the beneficial effects of enrichment. Expand
PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
TLDR
The data indicate that PLC-β1 activation via mGluR5 is critical for the coordinated development of the neocortex, and that presynaptic and postsynaptic components of cortical differentiation can be genetically dissociated. Expand
Gene–environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington’s disease transgenic mice
TLDR
Environmental enrichment enhanced spatial learning and significantly ameliorated this memory deficit in HD mice and delays the onset of a deficit in hippocampal PSD-95 levels, suggesting changes in synaptic composition may contribute to the cognitive alterations observed. Expand
Magnetic resonance imaging as an approach towards identifying neuropathological biomarkers for Huntington's disease
TLDR
This review examines contributions from structural MRI, fMRI and DTI studies to the current understanding of preclinical and clinical HD, and critically appraises MRI methods potentially suitable for both scientific characterisation and for use as biomarkers in HD clinical trials. Expand
Decreased hippocampal cell proliferation in R6/1 Huntington's mice
TLDR
It is shown that cell proliferation in the hippocampus was similar in younger asymptomatic R6/1 mice and wild type controls, but that older R6-1 mice had significantly fewer BrdU+ cells than controls, which may be relevant to some of the deficits seen in these mice. Expand
Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome –Mecp2 gene dosage effects and BDNF expression
TLDR
A positive impact of environmental enrichment in a Rett syndrome model is demonstrated and this impact may be dependent on the existence of one functional copy of Mecp2. Expand
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