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Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells.
The data indicate that anti-inflammatory properties of poncirin might be the result from the inhibition iNOS, COX-2, TNF-alpha and IL-6 expression via the down-regulation of NF-kappaB binding activity. Expand
Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells.
The findings suggest that the suppressive effect of iNOS gene expression by brazilin might provide one possible mechanism for its anti-inflammatory and cancer chemopreventive activity. Expand
Identification of a new naphthalene and its derivatives from the bulb of eleutherine americana with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
  • A. Han, H. Min, +6 authors E. Seo
  • Chemistry, Medicine
  • Chemical & pharmaceutical bulletin
  • 1 September 2008
A new naphthoquinone was isolated from the bulb of Eleutherine americana MERR together with two known compounds, eleutherinol and 1,5-dihydroxy-3-methylanthraquinone which were found in this species for the first time. Expand
Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).
Bioassay-guided fractionation of a chloroform-soluble extract of Garcinia mangostana stem bark, using the HT-29 human colon cancer cell line and an enzyme-based ELISA NF-kappaB assay, led to theExpand
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
A new prenylated chalcone, 3' ',3' '-dimethylpyrano[3',4']2,4,2'-trihydroxychalcone (1), was isolated from the heartwood of Artocarpus communis and the structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Expand
Pharmacokinetics of α-mangostin in rats after intravenous and oral application.
Although pure α-mangostin has shown a variety of pharmacological activities in in vitro assays at present it is uncertain if the same magnitude of effects will be achieved in vivo when its low bioavailability is considered. Expand
Cyclooxygenase-2 inhibitory phenylbutenoids from the rhizomes of Zingiber cassumunar.
Compound was elucidated as a new phenylbutenoid glycoside, namely, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-O-beta-D-glucopyranoside by spectral analysis including various 1D- and 2D-NMR experiments. Expand
Identification of a new cytotoxic biflavanone from Selaginella doederleinii.
A new biflavanone, 2,2'',3,3''-tetrahydrorobustaflavone 7,4',7''-trimethyl ether was isolated from the whole plant of Selaginella doederleinii HIERON and used as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. Expand
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
It is discovered that the kanamycin biosynthetic pathway contains an early branch point, governed by the substrate promiscuity of a glycosyltransferase, that leads to the formation of two parallel pathways in which early intermediates are further modified. Expand
Constituents of Asarum sieboldii with Inhibitory Activity on Lipopolysaccharide (LPS)‐Induced NO Production in BV‐2 Microglial Cells
Among the ten known isolates, compounds 1, 2, and 5 were found for the first time in this plant and showed potent inhibition of NO production, with IC50 values in the low nanomolar‐to‐micromolar range. Expand