• Publications
  • Influence
Rho GTPases and the actin cytoskeleton.
  • A. Hall
  • Biology, Medicine
  • 23 January 1998
Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Rho GTPases: biochemistry and biology.
  • A. Jaffe, A. Hall
  • Biology, Medicine
    Annual review of cell and developmental biology
  • 7 October 2005
This review presents the best characterized of these biochemical pathways that control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division.
Rho GTPases in cell biology
Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
Rho, a ras-related GTP-binding protein, rapidly stimulated stress fiber and focal adhesion formation when microinjected into serum-starved Swiss 3T3 cells, implying that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors.
Rho GTPases and their effector proteins.
The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of RhoGTPases in lower eukaryotes is making increasingly important contributions to this field.
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.
All the evidence points to GEFs being the critical mediators of Rho GTPase activation, and this paper reviews the present understanding of how they do this.
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Two distinct TOR complexes constitute a primordial signalling network conserved in eukaryotic evolution to control the fundamental process of cell growth.
Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement
  • C. Nobes, A. Hall
  • Biology, Medicine
    The Journal of cell biology
  • 22 March 1999
It is concluded that the signal transduction pathways controlled by the four small GTPases, Rho, Rac, Cdc42, and Ras, cooperate to promote cell movement.