Rho GTPases and the actin cytoskeleton.
- A. Hall
- BiologyScience
- 23 January 1998
Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
Rho GTPases: biochemistry and biology.
This review presents the best characterized of these biochemical pathways that control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division.
Rho GTPases in cell biology
- S. Etienne-Manneville, A. Hall
- BiologyNature
- 12 December 2002
Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
- A. Ridley, H. Paterson, C. Johnston, D. Diekmann, A. Hall
- BiologyCell
- 7 August 1992
Rho GTPases and their effector proteins.
- A. L. Bishop, A. Hall
- BiologyBiochemical Journal
- 1 June 2000
The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of RhoGTPases in lower eukaryotes is making increasingly important contributions to this field.
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
- E. Jacinto, R. Loewith, M. Hall
- BiologyNature Cell Biology
- 1 November 2004
Two distinct TOR complexes constitute a primordial signalling network conserved in eukaryotic evolution to control the fundamental process of cell growth.
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.
- A. Schmidt, A. Hall
- BiologyGenes & Development
- 1 July 2002
All the evidence points to GEFs being the critical mediators of Rho GTPase activation, and this paper reviews the present understanding of how they do this.
Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement
It is concluded that the signal transduction pathways controlled by the four small GTPases, Rho, Rac, Cdc42, and Ras, cooperate to promote cell movement.
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