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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
Although metformin is widely used for the treatment of non-insulin-dependent diabetes, its mode of action remains unclear. Here we provide evidence that its primary site of action is through a direct… Expand
Cyclosporin A binding in mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury
When loaded with high (pathological) levels of Ca2+, mitochondria become swollen and uncoupled as the result of a large non-specific increase in membrane permeability. This process, known as the… Expand
Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites.
Percoll-purified rat liver mitochondria were shown to contain BAX dimer and rapidly (<2 min) release 5-10% of their cytochrome c when incubated in a standard KCl incubation medium under energized… Expand
Energy Metabolism during Apoptosis
We have investigated cell metabolism during apoptosis in the murine interleukin-3 (IL-3)-dependent cell line Bo and two derivative clones (B14 and B15) overexpressing human bcl-2a. On removal of… Expand
Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pHi.
The pH-sensitive fluorescent indicator 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) was used to measure lactate transport in single cardiac myocytes. Addition of lactate externally caused… Expand
Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells.
We have used the intracellular pH-sensitive fluorescent dye 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) to characterize the substrate and inhibitor specificity of monocarboxylate… Expand
Evidence that the anti-diabetic actions of metformin are caused by a self-limiting inhibition of Complex I of the respiratory chain
Characterization of the Enhanced Transport of L- and D-Lactate into Human Red Blood Cells Infected with Plasmodium falciparum Suggests the Presence of a Novel Saturable Lactate Proton Cotransporter…
- S. Cranmer, A. Conant, W. Gutteridge, A. Halestrap
- Biology, Medicine
- The Journal of Biological Chemistry
- 23 June 1995
Human erythrocytes parasitized with the malarial protozoan Plasmodium falciparum showed rates of L-lactate, D-lactate, and pyruvate uptake many fold greater than control cells. Thus it was necessary… Expand
The pathway of electron flow through ubiquinol:cytochrome c oxidoreductase in the respiratory chain. Evidence from inhibition studies for a modified 'Q cycle'.
- A. Halestrap
- Chemistry, Medicine
- The Biochemical journal
- 15 April 1982
1. Cytochrome spectra of the liver and heart mitochondria incubated under various conditions are presented to compare the effects of antimycin, colletotrichin and 2-heptyl-4-hydroxyquinoline N-oxide… Expand