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The SLC16 gene family—from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
The monocarboxylate cotransporter (MCT) family now comprises 14 members, of which only the first four (MCT1–MCT4) have been demonstrated experimentally to catalyse the proton-linked transport ofExpand
The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.
There is still much work to be done to characterize the properties of the different MCT isoforms and their regulation, which may have wide-ranging implications for health and disease. Expand
Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.
The functional recovery of the Langendorff-perfused heart from ischaemia inversely correlates with the extent of pore opening, and inhibition of the MPTP provides protection against reperfusion injury. Expand
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
It is concluded that CD147 facilitates proper expression of MCT1 and MCT4 at the cell surface, where they remain tightly bound to each other, and may also be important in determining their activity and location. Expand
Role of calcium ions in regulation of mammalian intramitochondrial metabolism.
Ce rapport de synthese tente de fournir une vue generale sur les relations possibles qui existent entre les effets du Ca 2+ a l'interieur des mitochondries et le besoin d'ATP reclame par les cellulesExpand
The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism*
It is concluded that MCT4, like other glycolytic enzymes, is up-regulated by hypoxia through a HIF-1α-mediated mechanism, which allows the increased lactic acid produced during Hypoxia to be rapidly lost from the cell. Expand
Transport of lactate and other monocarboxylates across mammalian plasma membranes.
There are distinct Na(+)-monocarboxylate cotransporters on the luminal surface of intestinal and kidney epithelia, which enable active uptake of lactate, pyruvate, and ketone bodies in these tissues. Expand
What is the mitochondrial permeability transition pore?
  • A. Halestrap
  • Biology, Medicine
  • Journal of molecular and cellular cardiology
  • 1 June 2009
The authors' own studies implicate the mitochondrial phosphate carrier (PiC) in MPTP formation and are consistent with a calcium-triggered conformational change of the PiC, facilitated by CyP-D, inducing pore opening, and it is proposed that this is enhanced by an association of thePiC with the "c" conformation of the ANT. Expand
The permeability transition pore complex: another view.
The model is able to explain the mode of action of a wide range of known modulators of the MPTP that exert their effects by changing the binding affinity of the ANT for CyP-D, Ca(2+) or adenine nucleotides. Expand
The monocarboxylate transporter family—Structure and functional characterization
Site‐directed mutagenesis has identified key residues required for catalysis and inhibitor binding and enabled the development of a molecular model of MCT1 in both inward and outward facing conformations, which suggests a likely mechanism for the translocation cycle. Expand