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Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery.
Several grafted polypropylenimine dendrimers were synthesized by modifying either polypropylenimine (PPI) dendrimer generation 2 (G2) or generation 3 (G3) via 1.6-hexandioldiacrylate with branchedExpand
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Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.
Fat cell metabolism has an impact on body homeostasis and its proper function. Nevertheless, the knowledge about simultaneous metabolic processes, which occur during adipogenesis and in matureExpand
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Metabolic signatures differentiate ovarian from colon cancer cell lines
BackgroundIn this era of precision medicine, the deep and comprehensive characterization of tumor phenotypes will lead to therapeutic strategies beyond classical factors such as primary sites orExpand
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Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake
High-throughput screening techniques that analyze the metabolic endpoints of biological processes can identify the contributions of genetic predisposition and environmental factors to the developmentExpand
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Release of lysophospholipid ‘find-me’ signals during apoptosis requires the ATP-binding cassette transporter A1
Efficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. Apoptotic cells secure this process by releasing ‘find-me’ signals for theExpand
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Circulating microparticles in acute diabetic Charcot foot exhibit a high content of inflammatory cytokines, and support monocyte-to-osteoclast cell induction
Circulating microparticles (MPs) are major mediators in cardiovascular complications of type 2 diabetes (T2D); however, their contribution to Charcot foot (CF) disease is not known. Here, we purifiedExpand
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Nesting of colon and ovarian cancer cells in the endothelial niche is associated with alterations in glycan and lipid metabolism
The metabolic phenotype of a cancer cell is determined by its genetic makeup and microenvironment, which dynamically modulates the tumor landscape. The endothelial cells provide both a promoting andExpand
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Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects
Intensive diabetes control has been associated with increased mortality in type 2 diabetes (T2DM); this has been suggested to be due to increased hypoglycemia. We measured hypoglycemia-inducedExpand
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Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine
Metabolomics is a versatile unbiased method to search for biomarkers of human disease. In particular, one approach in cancer therapy is to promote apoptosis in tumour cells; this could be improvedExpand
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Metabolomics in cell culture--a strategy to study crucial metabolic pathways in cancer development and the response to treatment.
  • A. Halama
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 15 December 2014
Metabolomics is a comprehensive tool for monitoring processes within biological systems. Thus, metabolomics may be widely applied to the determination of diagnostic biomarkers for certain diseases orExpand
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