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Role of reactive oxygen species (ROS) in apoptosis induction
The role of ROS in the regulation of apoptosis, especially in inflammatory cells, is focused on, with particular attention to mitochondria.
Microassay of superoxide anion scavenging activity in vitro.
In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone.
It is reported that tPA contains 2 independent epitopes that exert opposite effects on blood vessel tone, and it is found that the vasopressor effect of PE is more pronounced in tPA knockout than in wild-type mice.
Binding of Urokinase to Low Density Lipoprotein-related Receptor (LRP) Regulates Vascular Smooth Muscle Cell Contraction*
- T. Nassar, A. Haj-Yehia, A. Higazi
- Biology, MedicineThe Journal of Biological Chemistry
- 25 October 2002
The in vitro and in vivo effects of infused uPA on aortic contractility and the restoration of normal blood pressure in uPA−/− mice were prevented by antibody to low-density lipoprotein receptor-related protein/α2-macroglobulin receptor (LRP).
Human alpha-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
Observations suggest that binding of alpha-Defensin to LRP expressed in SMCs leads to its internalization; internalized alpha-defensin binds to PKC and inhibits its enzymatic activity, leading to decreased Ca(++) mobilization and SMC contraction in response to PE.
Determination of lipoic acid and dihydrolipoic acid in human plasma and urine by high-performance liquid chromatography with fluorimetric detection.
Intrarenal nitric oxide monitoring with a Clark-type electrode: potential pitfalls.
- S. Heyman, F. Karmeli, D. Rachmilewitz, A. Haj-Yehia, M. Brezis
- Biology, MedicineKidney international
- 1 May 1997
With concomitant determination of intrarenal blood flow it could be a potent experimental tool for the evaluation of the role of NO in renal hemodynamics, and potential artifacts of NO monitoring, such as fluctuations in tissue oxygenation and temperature are evaluated.
Carbamazepine‐Valnoctamide Interaction in Epileptic Patients: In Vitro/In Vivo Correlation
In this study, VCD clearance was higher in epileptic patients (treated with CBZ) than in healthy subjects, and there was a striking similarity between in vitro and in vivo inhibition potencies.
Synchronized Release of Sulpiride and Sodium Decanoate from HPMC Matrices: A Rational Approach to Enhance Sulpiride Absorption in the Rat Intestine
- M. Baluom, M. Friedman, P. Assaf, A. Haj-Yehia, A. Rubinstein
- MedicinePharmaceutical Research
- 1 September 2000
SP bioavailability after intestinal administration can be improved only if SP is released together with SD along the entire intestinal route, and can be accomplished by the design of synchronous matrices capable of concomitant release of SP and SD despite the differences in their water solubility.
Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects
- M. Bialer, A. Haj-Yehia, N. Barzaghi, F. Pisani, E. Perucca
- Biology, MedicineEuropean Journal of Clinical Pharmacology
VCD appears to act as a drug in its own right, and it does not undergo similar hydrolysis to VPD, which may account for the different pharmacological activities of the two isomers.