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Tracking the Evolution of Non‐Small‐Cell Lung Cancer
TLDR
Intratumor heterogeneity mediated through chromosome instability was associated with an increased risk of recurrence or death, a finding that supports the potential value of chromosome instability as a prognostic predictor.
First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS).
The matching criteria were gestation (using an ultrasound crown–rump length or biparietal diameter measurement), duration of storage, and centre. Screening performance of the individual markers and
Tobacco and cancer: recent epidemiological evidence.
TLDR
The evidence now available shows that tobacco smoke is a multipotent carcinogenic mixture that can cause cancer in many different organs, and exposure to secondhand tobacco Smoke is also carcinogenic for the human lung.
First-trimester or second-trimester screening, or both, for Down's syndrome.
TLDR
First-trimester combined screening at 11 weeks of gestation is better than second- Trimester quadruple screening but at 13 weeks has results similar to second- trimester quadruples screening.
The accumulated evidence on lung cancer and environmental tobacco smoke
TLDR
The epidemiological and biochemical evidence on exposure to environmental Tobacco smoke, with the supporting evidence of tobacco specific carcinogens in the blood and urine of non-smokers exposed to environmental tobacco smoke, provides compelling confirmation that breathing other people's tobacco smoke is a cause of lung cancer.
Phylogenetic ctDNA analysis depicts early stage lung cancer evolution
TLDR
It is shown that phylogenetic ct DNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.
Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer.
TLDR
Low-dose radioiodine plus thyrotropin alfa was as effective as high-doseRadioiodine, with a lower rate of adverse events, in a randomized noninferiority trial of patients with differentiated thyroid cancer.
A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect
TLDR
Hip fracture in old age is a major adverse effect of smoking after the menopause, and the cumulative excess bone loss over decades is substantial, increasing the lifetime risk of hip fracture by about half.
Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls
TLDR
Birth defects that are positively associated with maternal smoking should now be included in public health educational materials to encourage more women to quit before or during pregnancy.
Tobacco smoke and involuntary smoking.
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