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Control of TH17 cells occurs in the Small Intestine
Interleukin (IL)-17-producing T helper cells (TH17) are a recently identified CD4+ T cell subset distinct from T helper type 1 (TH1) and T helper type 2 (TH2) cells. TH17 cells can driveExpand
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New markers for murine memory B cells that define mutated and unmutated subsets
The study of murine memory B cells has been limited by small cell numbers and the lack of a definitive marker. We have addressed some of these difficulties with hapten-specific transgenic (Tg) mouseExpand
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A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus
The precise role of B cells in systemic autoimmunity is incompletely understood. Although B cells are necessary for expression of disease (Chan, O., and M.J. Shlomchik. 1998. J. Immunol. 160:51–59,Expand
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Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone.
We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization,Expand
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Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
Although mucosal surfaces represent the main portal of entry for pathogens, the mechanism of antigen presentation by dendritic cells (DCs) that patrol various mucosal tissues remains unclear.Expand
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Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration
Tissue development and regeneration depend on cell–cell interactions and signals that target stem cells and their immediate progeny. However, the cellular behaviours that lead to a properlyExpand
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Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns.
Proliferation, mutation, and selection in the germinal center (GC) are thought to occur in distinct microanatomical compartments-the dark zone (DZ) and the light zone (LZ). Thus, affinity maturationExpand
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Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy.
An enigmatic feature of Lyme disease is the slow resolution of musculoskeletal symptoms that can continue after treatment, with some patients developing an inflammatory arthritis that becomesExpand
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NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
NLRs (nucleotide-binding domain leucine-rich-repeat-containing receptors; NOD-like receptors) are a class of pattern recognition receptor (PRR) that respond to host perturbation from eitherExpand
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Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner
Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognateExpand
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