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Cutaneous Inflammation and Proliferation in vitro: Differential Effects and Mode of Action of Topical Glucocorticoids
PC is revealed as the only glucocorticoid with an improved benefit/risk ratio verified clinically and in vitro and is shown to be almost ineffective and DCE presents exactly the opposite features of PC.
Drug Targeting by Solid Lipid Nanoparticles for Dermal Use
Interestingly, PC incorporation into nanoparticles appeared to induce a localizing effect in the epidermal layer which was pronounced at 6 h and declined later, and may increase the benefit/risk ratio of topical therapy.
Prednicarbate Versus Conventional Topical Glucocorticoids: Pharmacodynamic Characterization In Vitro
Correlating antiphlogistic effects in keratinocytes with antiproliferative effects in fibroblasts suggests the improved benefit−risk ratio of PC compared to conventional glucocorticoids does not result only from distinct drug metabolism in the skin but also from a specific influence on the cytokine network.
Skin Penetration and Metabolism of Topical Glucocorticoids in Reconstructed Epidermis and in Excised Human Skin
In vitro determination of the dermal 17-monoesters concentrations may allow the prediction of the atrophogenic risk in man and the inactivation of highly potent, but also cell toxic, 17- monoesters to almost inactive 21-congeners appears less important in the skin.
Prednicarbate Biotransformation in Human Foreskin Keratinocytes and Fibroblasts
Based on the results to the in-vivo situation, topically applied PC may be metabolized by epidermal cells during skin penetration, a complex mixture of compounds reaches the dermis, whose fibroblasts are barely able to metabolize the steroids.