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Liquid chromatography–mass spectrometry (LC–MS) of steroid hormone metabolites and its applications
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Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range.
TLDR
By monitoring the negative ions that were formed, it was possible to obtain attomole sensitivity for pentafluorobenzyl derivatives of a representative steroid, steroid metabolite, prostaglandin, thromboxane, amino acid, and DNA-adduct.
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Highly cytotoxic bioconjugated gold(I) complexes with cysteine-containing dipeptides.
TLDR
The complexes show an outstanding cytotoxic activity with IC50 values in the very low micromolar range and structure-activity relationship studies from the complexes open the possibility of designing more potent and promising gold(I) anticancer agents.
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Synthesis, characterization, and cytotoxic activity of AuI N,S-heterocyclic carbenes derived from peptides containing L-thiazolylalanine
The authors thank the Ministerio de Economia y Competitividad (MEC/FEDER) (grant numbers CTQ2010-20500-C02-01, SAF2010-14920) and the Gobierno de Aragon-Fondo Social Europeo (DGA-FSE) (DGA-FSE) (E77)…
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Gold(I) thiolates containing amino acid moieties. Cytotoxicity and structure-activity relationship studies.
TLDR
Observations of different cellular events after addition of the complexes indicated the possible mechanism of action or the biological targets of this type of new gold(I) drug.
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Synthesis of new gold(I) thiolates containing amino acid moieties with potential biological interest.
TLDR
The reaction of the gold(I) complex, which contains nicotinic acid thiolate, with several amino acid esters such as glycine methyl ester, has been characterized by X-ray crystallography, showing, in the second case, only one of the enantiomers, which proves that retention of the configuration after reaction occurs.
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Bioactive gold(i) complexes with 4-mercaptoproline derivatives.
TLDR
Structural-Activity Relationships (SAR) observed from this family of complexes opens the possibility of designing more potent and selective promising gold(i) anticancer agents.
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HIV-1 inhibiting capacity of novel forms of presentation of GB virus C peptide domains is enhanced by coordination to gold compounds.
TLDR
The design and synthesis of new forms of presentation of two peptide inhibitors corresponding to the envelope proteins E1 and E2 of GBV-C, together with a study of their anti-HIV-1 activity support the putative modulation of HIV-1 infection by the GBv-C E1 protein and open new perspectives for the development of novel peptide-derived HIV- 1 entry inhibitors.
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(S)‐Naproxen® as a Derivatizing Agent to Determine Enantiomeric Excess of Cyanohydrins by HPLC.
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Synthesis of cis- and trans-(±)-3-mercaptoproline and pipecolic acid derivatives via thio-Michael addition
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