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Rapid induction of seven proteins in human lymphocytes by interferon; correlation to natural killer cell activity.
- A. Gustafsson, S. Sundström, T. Ny, E. Lundgren
- Biology, Medicine
- Journal of immunology
- 1 November 1982
The early effects of interferon (IFN) on the synthesis of protein in human nylon wool-nonadherent lymphocytes have been stimulated by use of two-dimensional electrophoresis. IFN-alpha or -beta as… Expand
The augmentation of human natural killer cell activity by interferon-gamma is not associated with the induction of the interferon-alpha-inducible proteins.
Treatment of partly purified large granular lymphocytes (LGL) with either IFN-alpha or IFN-gamma for 2 hr augmented their NK cell activity. This augmentation was completely inhibited by the addition… Expand
Augmentation of natural killer cells involves both enhancement of lytic machinery and expression of new receptors.
Abstract A good correlation was found between the sensitivity of six hematopoetic cell lines to natural killing by both unstimulated and Interferon (IFN)-stimulated effector cells and the ability of… Expand
Similar Effects of Treatment with α Interferon on the Protein Synthesis of Human Large Granular Lymphocytes, T Cells, and Monocytes
Preparations of human large granular lymphocytes (LGL), T cells, and monocytes (MC) were obtained through centrifugation on Percoll gradients and preparative E‐rosetting. The different preparations… Expand
Identification andcharacterization ofacis-acting element that interferes withglucocorticoid-i
Therathepatoma cell line Ml.19isstably infected bythemousemammarytumor virus (MMTV), andthe expression ofthevirus isinduced byglucocorticoid treatment. However, inthe6.10.2 variant ofM1.19,… Expand
Transcript profiles and genotyping of cancer tissue
Down-regulation ofglucocorticoid receptor mRNA byglucocorticoid hormones andrecognition bythereceptor ofaspecific binding sequence within areceptor cDNAclone
- A Gustafsson
A cDNAclone fortheratglucocorticoid receptor (GR)wasusedtostudy mechanisms ofGR mRNA regulation. Treatment ofrathepatoma culture cells with0.5 MAMdexamethasone caused asmall, initial increase intheGR… Expand
cDNAcloning, sequence, andregulation ofamajorfemale-specific andgrowth hormone-inducible ratliver cytochrome P-450active in15f-hydroxylation ofsteroid sulfates
ABSTRACT cDNAclonesencompassingthecompletecod-ing sequence for the female-specific rat liver microsomal 15.8-hydroxylase have been isolated and sequenced. This cy-tochrome P-450 species (P.450 15/3)… Expand