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UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
The Fanconi anemia pathway is required for the efficient repair of damaged DNA. A key step in this pathway is the monoubiquitination of the FANCD2 protein by the ubiquitin ligase (E3) composed of… Expand
The role of miRNAs in regulating gene expression networks.
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across species, expressed across cell types, and active against a large proportion of the transcriptome. The… Expand
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.
Dicer is an RNase III family endoribonuclease and haploinsufficient tumor suppressor that processes mature miRNAs from the 5' (5p) or 3' (3p) arm of hairpin precursors. In murine Dicer knockout… Expand
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.
MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein coding genes, including many involved in basal cellular processes and organismal development.… Expand
Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements.
MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it… Expand
Catecholamines Are Required for the Acquisition of Secretory Responsiveness by Sweat Glands
- H. Tian, B. Habecker, +4 authors S. Landis
- Medicine, Biology
- The Journal of Neuroscience
- 1 October 2000
The sympathetic innervation of sweat glands undergoes a developmental change in transmitter phenotype from catecholaminergic to cholinergic. Acetylcholine elicits sweating and is necessary for… Expand
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell… Expand
Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.
- Courtney K Jnbaptiste, A. Gurtan, +6 authors P. Sharp
- Biology, Medicine
- Genes & development
- 1 April 2017
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression critical for organismal viability. Changes in miRNA activity are common in cancer, but how these changes relate to subsequent… Expand
Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex
Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.
Courtney K. JnBaptiste, Allan M. Gurtan, Kevin K. Thai, Victoria Lu, Arjun Bhutkar, Mei-Ju Su, Asaf Rotem, Tyler Jacks, and Phillip A. Sharp Department of Biology, Massachusetts Institute of… Expand