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Hippocampal Replay Is Not a Simple Function of Experience
Replay of behavioral sequences in the hippocampus during sharp wave ripple complexes (SWRs) provides a potential mechanism for memory consolidation and the learning of knowledge structures. CurrentExpand
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Segmentation of spatial experience by hippocampal theta sequences
The encoding and storage of experience by the hippocampus is essential for the formation of episodic memories and the transformation of individual experiences into semantic structures such as mapsExpand
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Multiscale Fluctuation-Based Dispersion Entropy and Its Applications to Neurological Diseases
TLDR
Fluctuation-based dispersion entropy (FDispEn) is a new approach to estimate the dynamical variability of the fluctuations of signals. Expand
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Computer mouse use captures ataxia and parkinsonism, enabling accurate measurement and detection
Objective assessments of movement impairment are needed to support clinical trials and facilitate diagnosis. The objective of the current study was to determine if a rapid web‐based computer mouseExpand
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Behavioral Correlates of Hippocampal Neural Sequences
Sequences of neural activity representing paths in an environment are expressed in the rodent hippocampus at three distinct time scales, with different hypothesized roles in hippocampal function. AsExpand
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Spontaneous rupture of lens capsule with dislocation of nucleus in hypermature cataract.
We report a case of spontaneous rupture of the lens capsule in a woman with hypermature cataract, who presented to us with nucleus dislocation in the posterior chamber of her left eye. The capsuleExpand
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"I think we know more than our doctors"
TLDR
We report on the responsibilities that the primary caregivers take on in response to care teams' lack of experience with the illness, and the ways in which an online health community supports this care coordination work. Expand
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From novices to co-pilots: Fixing the limits on scientific knowledge production by accessing or building expertise
TLDR
The current approach of relying primarily on institutional experts to create knowledge to solve humanity's problems is insufficient to meet the scale, diversity, and novelty of people's needs. Expand
Accurate detection of cerebellar smooth pursuit eye movement abnormalities via mobile phone video and machine learning
TLDR
We demonstrate that it is feasible to extract iris position data from consumer-grade device video recordings during the performance of standard oculomotor tasks such as smooth pursuit. Expand
A pilot protocol to assess the feasibility of a virtual multiple crossover, randomized controlled trial design using methylphenidate in mild cognitive impairment
The conventional clinical trial design in Alzheimer’s disease (AD) and AD-related disorders (ADRDs) is the parallel-group randomized controlled trial. However, in heterogeneous disorders likeExpand