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Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data
- A. Edwards, P. Brocklehurst, +7 authors D. Azzopardi
- BMJ : British Medical Journal
- 9 February 2010
Objective To determine whether moderate hypothermia after hypoxic-ischaemic encephalopathy in neonates improves survival and neurological outcome at 18 months of age. Design A meta-analysis was… Expand
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
- A. Gunn, T. Gunn, H. H. de Haan, C. Williams, P. Gluckman
- The Journal of clinical investigation
- 15 January 1997
Hypothermia has been proposed as a neuroprotective strategy. However, short-term cooling after hypoxia-ischemia is effective only if started immediately during resuscitation. The aim of this study… Expand
Mechanisms of hypothermic neuroprotection.
There is now compelling clinical evidence that prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia-ischemia and continued until resolution of the acute phase of… Expand
Selective Head Cooling in Newborn Infants After Perinatal Asphyxia: A Safety Study
Aims. To determine the practicality and safety of head cooling with mild or minimal systemic hypothermia in term neonates with moderate to severe hypoxic-ischemic encephalopathy. Methods. Study group… Expand
Outcome after ischemia in the developing sheep brain: An electroencephalographic and histological study
The role of seizures occurring with perinatal hypoxic‐ischemic encephalopathies is unclear. We examined the relationships between the time course of parasagittal electroencephalographic (EEG)… Expand
The importance of ‘awareness’ for understanding fetal pain
Our understanding of when the fetus can experience pain has been largely shaped by neuroanatomy. However, completion of the cortical nociceptive connections just after mid-gestation is only one part… Expand
Determinants of Outcomes After Head Cooling for Neonatal Encephalopathy
OBJECTIVE. The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy.… Expand
Cerebral Hypothermia Is Not Neuroprotective When Started after Postischemic Seizures in Fetal Sheep
Prolonged cerebral hypothermia is neuroprotective if started within a few hours of hypoxia-ischemia. However, delayed seizure activity is one of the major clinical indicators of an adverse prognosis… Expand
The intrapartum deceleration in center stage: a physiologic approach to the interpretation of fetal heart rate changes in labor.
- J. Westgate, B. Wibbens, L. Bennet, G. Wassink, J. Parer, A. Gunn
- American journal of obstetrics and gynecology
- 1 September 2007
One of the most distinctive features of fetal heart rate recordings in labor is the deceleration. In clinical practice, there has been much confusion about the types of decelerations and their… Expand
Maturational Change in the Cortical Response to Hypoperfusion Injury in the Fetal Sheep
A characteristic of perinatal encephalopathies are the distinct patterns of neuronal and glial cell loss. Cerebral hypoperfusion is thought to be a major cause of these lesions. Gestational age is… Expand