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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy. Because these effects are in part determined by p53-mediated apoptosis, temporary suppression… Expand
Structural Basis of TLR5-Flagellin Recognition and Signaling
Flagellin Takes Its Toll The immune system recognizes bacterial infections by binding to conserved molecular fragments derived from the invading bacteria. Molecular mimics of these bacterial… Expand
An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models
The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to… Expand
The role of p53 in determining sensitivity to radiotherapy
Ionizing radiation (IR) has proven to be a powerful medical treatment in the fight against cancer. Rational and effective use of its killing power depends on understanding IR-mediated responses at… Expand
The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control
- I. Garkavtsev, I. Grigorian, V. Ossovskaya, M. V. Chernov, P. Chumakov, A. Gudkov
- Medicine, Biology
- 15 January 1998
The candidate tumour-suppressor gene ING1 has been identified by using the genetic suppressor element (GSE) methodology. ING1 encodes a nuclear protein, p33ING1, overexpression of which inhibits… Expand
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.
- V. S. Ossovskaya, I. B. Mazo, +6 authors A. Gudkov
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 17 September 1996
p53 is a multifunctional tumor suppressor protein involved in the negative control of cell growth. Mutations in p53 cause alterations in cellular phenotype, including immortalization, neoplastic… Expand
Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability
cDNA microarray hybridization was used in an attempt to identify novel genes participating in cellular responses to prolonged hypoxia. One of the identified novel genes, designated Hi95 shared… Expand
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
Abstractp53-dependent apoptosis contributes to the side effects of cancer treatment, and genetic or pharmacological inhibition of p53 function can increase normal tissue resistance to genotoxic… Expand
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
The systemic administration of keratinocyte growth factor (KGF) enhances T-cell lymphopoiesis in normal mice and mice that received a bone marrow transplant. KGF exerts protection to thymic stromal… Expand
Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription
- M. Spengler, K. Kuropatwinski, +8 authors M. Antoch
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 15 August 2012
The circadian clock controls many physiological parameters including immune response to infectious agents, which is mediated by activation of the transcription factor NF-κB. It is widely accepted… Expand