Share This Author
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
This study has shown that a small molecule isolated for its ability to reversibly block p53-dependent transcriptional activation and apoptosis protected mice from the lethal genotoxic stress associated with anticancer treatment without promoting the formation of tumors.
Structural Basis of TLR5-Flagellin Recognition and Signaling
The crystal structure of zebrafish TLR5 (as a variable lymphocyte receptor hybrid protein) in complex with the D1/D2/D3 fragment of Salmonella flagellin, FliC, is determined at 2.47 angstrom resolution.
An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models
CBLB502, a polypeptide drug derived from Salmonella flagellin that binds to Toll-like receptor 5 (TLR5) and activates nuclear factor–κB signaling, protected mice from both gastrointestinal and hematopoietic acute radiation syndromes and resulted in improved survival.
The role of p53 in determining sensitivity to radiotherapy
Understanding mechanisms of IR-mediated responses at the molecular, cellular and tissue levels indicates new rational approaches to improving cancer treatment by IR.
Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability
Conditional overexpression of the Hi95 cDNA in MCF7-tet-off cells resulted in their protection against cell death induced by hypoxia/glucose deprivation or H2O2, suggesting Hi95 gene seems to be involved in complex regulation of cell viability in response to different stress conditions.
The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control
- I. Garkavtsev, I. Grigorian, V. Ossovskaya, M. Chernov, P. Chumakov, A. Gudkov
- 15 January 1998
The results indicate that p33ING1 is a component of the p53 signalling pathway that cooperates with p53 in the negative regulation of cell proliferation by modulating p53-dependent transcriptional activation.
Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation
It is demonstrated that ING1 can act as a potent growth regulator in normal and in established cells and provide evidence for a role as a candidate tumour suppressor gene whose inactivation may contribute to the development of cancers.
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
Results indicate that selective inhibition of the mitochondrial branch of the p53 pathway is sufficient for radioprotection in vivo.
Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription
- M. Spengler, K. Kuropatwinski, M. Antoch
- BiologyProceedings of the National Academy of Sciences
- 15 August 2012
It is shown that daily variations in the intensity of the NF-κB response to a variety of immunomodulators are mediated by core circadian protein CLOCK, which can up-regulate NF-σκB–mediated transcription in the absence of BMAL1; moreover, BMal1 counteracts the CLOCK-dependent increase in the activation of NF-β–responsive genes.
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.
- V. Ossovskaya, I. Mazo, A. Gudkov
- BiologyProceedings of the National Academy of Sciences…
- 17 September 1996
It is suggested that processes related to control of senescence, response to DNA damage, and transformation involve different functions of the p53 protein and furthermore indicate a regulatory role for the 3'-untranslated region of p53 mRNA.