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Identification of Restricted Subsets of Mature microRNA Abnormally Expressed in Inactive Colonic Mucosa of Patients with Inflammatory Bowel Disease
TLDR
This study supports miRNAs as crucial players in the onset and/or relapse of inflammation from quiescent mucosal tissues in IBD patients and suggests that some of the miRNA with altered expression in the quiescence mucosa of I BD patients may define miRNA signatures for UC and CD and help develop new diagnostic biomarkers.
Chick oviduct glucocorticosteroid receptor. Specific binding of the synthetic steroid RU 486 and immunological studies with antibodies to chick oviduct progesterone receptor.
TLDR
The glucocorticosteroid receptor (GR) has been studied in oviduct cytosol prepared from estrogen-primed, 4-week-withdrawn chicken and dexamethasone was found not to be the best GR ligand.
Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis.
TLDR
Colonic mucosa samples from patients with UC have defects in the eIF2α pathway that controls protein translation and the cell stress response, and this pathway might be investigated to identify new therapeutic targets for patients withUC.
Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro
TLDR
The results suggest that the lack of affinity for DNA of the 8S form of GR may be attributable in vivo to the interaction of the 4S-GR protein with hsp 90, and that hormone binding might trigger a conformational change which results in the release of active 4s-GR.
NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon
TLDR
It is concluded that NADPH oxidase 1 controls the balance between goblet and absorptive cell types in the colon by coordinately modulating PI3K/AKT/Wnt/β-catenin and Notch1 signaling.
Insulin Activates Nuclear Factor κB in Mammalian Cells through a Raf-1-mediated Pathway (*)
TLDR
This is the first evidence that insulin activates NF-κB in mammalian cells through a post-translational mechanism requiring both insulin receptor tyrosine kinase and Raf-1 kinase activities.
Neuro-Steroids: 3β-Hydroxy-Δ5-Derivatives in the Rat Brain
The relationship between steroid hormones and brain function has mostly been considered according to the responses elicited by the secretory products of steroidogenic endocrine glands, generally in
Expression from the tyrosine aminotransferase promoter (nt -350 to +1) is liver-specific and dependent on the binding of both liver-enriched and ubiquitous trans-acting factors.
TLDR
Results from computer-assisted search of homologies, DNase I footprinting, gel retardation and methylation interference assays support the conclusion that TAT0.35 was able to sustain at least part of the liver specificity of TAT gene expression.
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